健康青少年的前庭诱发肌源性电位

Vestibular evoked myogenic potential in healthy adolescents.

作者信息

Brix Gitte Stokvad, Ovesen Therese, Devantier Louise

机构信息

Department of Clinical Medicine, Aarhus University, Nørrebrogade 44, 8000, Aarhus C, Denmark.

Department of Clinical Medicine, Aarhus University, Nørrebrogade 44, 8000, Aarhus C, Denmark; Department of Otorhinolaryngology, Region Hospital Holstebro, Lægårdvej 12, 7500, Holstebro, Denmark.

出版信息

Int J Pediatr Otorhinolaryngol. 2019 Jan;116:49-57. doi: 10.1016/j.ijporl.2018.10.019. Epub 2018 Oct 13.

DOI:10.1016/j.ijporl.2018.10.019

PMID:30554707

Abstract

OBJECTIVE

Vestibular dysfunction, which may lead to delayed motor development and reduced quality of life, is an overlooked entity among children and adolescents. Vestibular evoked myogenic potential (VEMP) is a common, safe diagnostic tool in adults with vestibular disorders. No normative data exist for children and adolescents. Our objective was to collect and assess normative VEMP data for adolescents.

METHODS

Cervical VEMP (cVEMP) with air-conducted sound. Endpoints were peak latencies after 13 and 23 ms (P13 and N23) and amplitude. Ocular VEMP (oVEMP) with bone-conducted vibration on the mastoid. Endpoints were latencies (N10 and P15) and amplitude. A meta-analysis of existing cVEMP data in children.

RESULTS

cVEMP response rate (RR) was 85%, mean P13 and N23 latencies were 15.44 and 25.55 ms, respectively, and the asymmetry ratio (AR) was 14%. oVEMP RR was 100%, mean N10 and P15 were 10.61 and 16.58 ms, respectively, and the AR was 12%. In the meta-analysis, the pooled mean P13 and N23 were 12.75 and 21.8 ms, respectively. Head elevation (HE) gave shorter latencies than head rotation (HR).

CONCLUSION

The oVEMP data represents normal values for adolescents aged 13-16 years. Height should be considered more important than age when interpreting cVEMP in adolescents. Separate normative cVEMP data should be established for HE and HR.

摘要

目的

前庭功能障碍在儿童和青少年中常被忽视，它可能导致运动发育迟缓及生活质量下降。前庭诱发肌源性电位（VEMP）是成人前庭疾病常用的安全诊断工具。目前尚无儿童和青少年的正常参考数据。我们的目的是收集并评估青少年VEMP的正常参考数据。

方法

采用气导声音刺激记录颈肌前庭诱发肌源性电位（cVEMP）。观察指标为13毫秒和23毫秒后的峰潜伏期（P13和N23）及波幅。采用乳突骨导振动刺激记录眼肌前庭诱发肌源性电位（oVEMP）。观察指标为潜伏期（N10和P15）及波幅。对已有的儿童cVEMP数据进行荟萃分析。

结果

cVEMP的引出率（RR）为85%，平均P13和N23潜伏期分别为15.44毫秒和25.55毫秒，不对称率（AR）为14%。oVEMP的RR为100%，平均N10和P15分别为10.61毫秒和16.58毫秒，AR为12%。荟萃分析中，合并后的平均P13和N23分别为12.75毫秒和21.8毫秒。抬头（HE）时的潜伏期比转头（HR）时短。