Institute of Medical Microbiology and Hygiene, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Trends Microbiol. 2019 Feb;27(2):89-90. doi: 10.1016/j.tim.2018.11.010. Epub 2018 Dec 13.
The membrane pore-forming α-toxin is an important virulence factor of Staphylococcus aureus. Target cells can remove pores from their surface, but recent work shows that α-toxin may undermine this self-defense by clinging to epithelial cell junctions. The findings could lead to the development of novel remedies against S. aureus infections.
膜孔形成α-毒素是金黄色葡萄球菌的重要毒力因子。靶细胞可以从其表面去除孔，但最近的研究表明，α-毒素可能通过黏附在上皮细胞连接上来破坏这种自我防御。这些发现可能会导致开发针对金黄色葡萄球菌感染的新疗法。
