趋化因子及其受体在扁桃体肥大和慢性扁桃体炎情况下的表达差异。
The differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitis.
作者信息
Koclu Hetemoglu Elif, Turkoglu Babakurban Seda, Terzi Yunus Kasım, Sahin Feride Iffet, Erbek Selim Sermed
机构信息
Başkent University Department of Otorhinolaryngology, Fevzi Cakmak Avenue 5(th) Street No: 48 06490 Bahcelievler, Ankara, Turkey.
Başkent University Department of Medical Genetics, Sehit H. Temel Kuguoglu Avenue No:34 06490 Bahcelievler, Ankara, Turkey.
出版信息
Auris Nasus Larynx. 2019 Aug;46(4):565-569. doi: 10.1016/j.anl.2018.12.001. Epub 2018 Dec 13.
OBJECTIVE
Fractalkine, member of chemokine family, is involved in many inflammatory processes in the human body. The aim of this study is to compare expression levels of fractalkine ligand and its receptor in chronic tonsillitis and hypertrophic tonsil samples.
METHODS
The study was conducted at Baskent University Departments of Otorhinolaryngology and Medical Genetics. It is designed as a prospective, non-randomized, controlled clinical study. Total 97 samples, obtained from adenotonsillectomy due to chronic tonsillitis or tonsillar hypertrophy, were participated in the study. Fractalkine and its receptor expression levels were determined and comparison was made between the tissue groups. c.839C>T (T280M) polymorphism of fractalkine receptor was analyzed, then relationship between polymorphism and the expression level of fractalkine receptor was investigated.
RESULTS
Fractalkine receptor expression was significantly higher in the hypertrophic tonsil group than chronic tonsillitis group (p<0.05).
CONCLUSION
Fractalkine, member of chemokine family, and its receptor may play role in preventing chronic-recurrent tonsillitis.
目的
趋化因子家族成员 fractalkine 参与人体多种炎症过程。本研究旨在比较慢性扁桃体炎和肥大扁桃体样本中 fractalkine 配体及其受体的表达水平。
方法
本研究在巴斯肯特大学耳鼻咽喉科和医学遗传学系进行。设计为前瞻性、非随机、对照临床研究。共有97份因慢性扁桃体炎或扁桃体肥大行腺样体扁桃体切除术获得的样本参与本研究。测定 fractalkine 及其受体表达水平，并在组织组间进行比较。分析 fractalkine 受体的 c.839C>T（T280M）多态性，然后研究多态性与 fractalkine 受体表达水平之间的关系。
结果
肥大扁桃体组中 fractalkine 受体表达显著高于慢性扁桃体炎组（p<0.05）。
结论
趋化因子家族成员 fractalkine 及其受体可能在预防慢性复发性扁桃体炎中发挥作用。
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