Cirugia cardiovascular, Hospital Nacional de Pediatria J. P. Garrahan, Ciudad Autonoma de Buenos Aires, Argentina.
Department of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.
J Thorac Cardiovasc Surg. 2019 Jan;157(1):126-132. doi: 10.1016/j.jtcvs.2018.07.113. Epub 2018 Oct 24.
Aortic valve repair is currently in transition from surgical improvisation to a reproducible operation and an option for many patients with aortic regurgitation. Our research efforts at improving reproducibility include development of methods for intraoperatively testing and visualizing the valve in its diastolic state.
We developed a device that can be intraoperatively secured in the transected aorta allowing the aortic root to be pressurized and the closed valve to be inspected endoscopically. Our device includes a chamber that can be pressurized with crystalloid solution and ports for introduction of an endoscope and measuring gauges. We show use of the device in explanted porcine hearts to visualize the aortic valve and to measure leaflet coaptation height in normal valves and in valves that have undergone valve repair procedures.
The procedure of introducing and securing the device in the aorta, pressurizing the valve, and endoscopically visualizing the closed valve is done in less than 1 minute. The device easily and reversibly attaches to the aortic root and allows direct inspection of the aortic valve under conditions that mimic diastole. It enables the surgeon to intraoperatively study the valve immediately before repair to determine mechanisms of incompetence and immediately after the repair to assess competence. We also show its use in measuring valve leaflet coaptation height in the diastolic state.
This device enables more relevant prerepair valve assessment and also enables a test of postrepair valve competence under physiological pressures.
主动脉瓣修复术目前正从外科手术的即兴发挥向可重复操作转变,成为许多主动脉瓣反流患者的选择。为了提高可重复性,我们致力于开发术中测试和可视化舒张期瓣膜的方法。
我们开发了一种可在术中固定于切断的主动脉内的设备,从而使主动脉根部能够加压,并且可以在内窥镜下检查关闭的瓣膜。我们的设备包括一个可以用晶体溶液加压的腔室,以及用于引入内窥镜和测量仪表的端口。我们展示了该设备在取出的猪心上的使用,以可视化主动脉瓣,并测量正常瓣膜和已接受瓣膜修复手术的瓣膜的瓣叶对合高度。
将设备引入和固定在主动脉内、给瓣膜加压以及在内窥镜下可视化关闭的瓣膜的过程不到 1 分钟即可完成。该设备轻松且可逆转地连接到主动脉根部,并允许在模拟舒张期的条件下直接检查主动脉瓣。它使外科医生能够在修复前即刻对瓣膜进行术中研究,以确定关闭不全的机制,并在修复后即刻评估瓣膜的功能。我们还展示了其在测量舒张期瓣叶对合高度方面的应用。
该设备能够更有效地评估术前瓣膜,并在生理压力下测试术后瓣膜功能。