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左半侧急性恶性结直肠梗阻的手术桥接与紧急手术治疗 - 疗效、安全性和长期结局。

Bridge-to-surgery versus emergency surgery in the management of left-sided acute malignant colorectal obstruction - Efficacy, safety and long-term outcomes.

机构信息

Gastroenterology Department, Centro Hospitalar São João, Porto, Portugal.

Gastroenterology Department, Centro Hospitalar São João, Porto, Portugal.

出版信息

Dig Liver Dis. 2019 Mar;51(3):364-372. doi: 10.1016/j.dld.2018.11.006. Epub 2018 Nov 20.


DOI:10.1016/j.dld.2018.11.006
PMID:30558864
Abstract

OBJECTIVE: Compare efficacy, safety and long-term outcomes of bridge-to-surgery and emergency surgery in acute malignant colorectal obstruction. METHODS: Retrospective study of 94 consecutive patients with left-sided acute malignant colorectal obstruction treated with curative intent between 2010-2017. RESULTS: 48 patients underwent stent placement and 46 underwent emergency surgery. Technical and clinical success were 100% and 87%. Laparoscopy and one-staged operation were more frequent in bridge-to-surgery (44% vs 2%, p < 0.001; 73% vs 30%, p < 0.001). Fewer permanent stomas were created in bridge-to-surgery (15% vs 35%, p = 0.013). Overall morbidity was 36%. Immediate and post-procedure stent related-complications occurred in 6% and 13%; surgery-related complications occurred in 28% (bridge-to-surgery: 15% vs emergency surgery: 41%, p = 0.004). No differences were found regarding tumor recurrence, recurrence-free survival and overall survival. R1 resection (HR 47.2, CI:4.1-543.7), number of lymph nodes harvested (HR 0.9 CI:0.8-0.99) and adjuvant therapy (HR 0.1 CI:0.01-0.9) predicted recurrence-free survival; pTMN stage IV (HR 7.3, CI:1.1-47.6), number of lymph nodes harvested (HR 0.90, CI:0.8-0.97), adjuvant therapy (HR 0.1, CI:0.02-0.4) and surgery-related complications (HR 5.3, CI:1.02-27.3) influenced overall survival. CONCLUSION: Stent placement has a high success, similarly to emergency surgery, being associated with higher primary anastomosis and lower stoma rates. Tumor recurrence rate, recurrence-free survival and overall survival were comparable between groups; surgery-related complications influenced overall survival.

摘要

目的:比较桥接手术与急诊手术治疗急性恶性结直肠梗阻的疗效、安全性和长期结果。 方法:回顾性分析 2010 年至 2017 年间接受根治性治疗的 94 例左侧急性恶性结直肠梗阻患者。 结果:48 例患者行支架置入术,46 例行急诊手术。技术和临床成功率均为 100%和 87%。桥接手术组腹腔镜和一期手术更为常见(44%比 2%,p<0.001;73%比 30%,p<0.001)。桥接手术组永久性造口更少(15%比 35%,p=0.013)。总并发症发生率为 36%。即刻和术后支架相关并发症发生率分别为 6%和 13%;手术相关并发症发生率分别为 28%(桥接手术组:15%比急诊手术组:41%,p=0.004)。两组肿瘤复发、无复发生存率和总生存率无差异。R1 切除(HR 47.2,CI:4.1-543.7)、淋巴结清扫数目(HR 0.9 CI:0.8-0.99)和辅助治疗(HR 0.1 CI:0.01-0.9)预测无复发生存率;pTMN 分期 IV(HR 7.3,CI:1.1-47.6)、淋巴结清扫数目(HR 0.90,CI:0.8-0.97)、辅助治疗(HR 0.1,CI:0.02-0.4)和手术相关并发症(HR 5.3,CI:1.02-27.3)影响总生存率。 结论:支架置入术成功率高,与急诊手术相似,与更高的一期吻合率和更低的造口率相关。两组肿瘤复发率、无复发生存率和总生存率相当;手术相关并发症影响总生存率。

相似文献

[1]
Bridge-to-surgery versus emergency surgery in the management of left-sided acute malignant colorectal obstruction - Efficacy, safety and long-term outcomes.

Dig Liver Dis. 2018-11-20

[2]
Colonic stent placement as a bridge to surgery in patients with left-sided malignant large bowel obstruction. An observational study.

G Chir. 2014

[3]
Colonic perforation either during or after stent insertion as a bridge to surgery for malignant colorectal obstruction increases the risk of peritoneal seeding.

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[4]
A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction.

Dis Colon Rectum. 2013-4

[5]
Colonic self-expanding metal stent (SEMS) as a bridge to surgery in left-sided malignant colonic obstruction: an 8-year review.

Surg Endosc. 2017-5

[6]
Does Stenting as a Bridge to Surgery in Left-Sided Colorectal Cancer Obstruction Really Worsen Oncological Outcomes?

Dis Colon Rectum. 2016-8

[7]
Bridge-to-surgery stent placement versus emergency surgery for acute malignant colonic obstruction.

Br J Surg. 2014-4-16

[8]
Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials.

Eur J Surg Oncol. 2020-5-7

[9]
Emergency management with resection versus proximal stoma or stent treatment and planned resection in malignant left-sided colon obstruction.

World J Surg Oncol. 2016-8-30

[10]
Self-expandable stent before elective surgery vs. emergency surgery for the treatment of malignant colorectal obstructions: comparison of primary anastomosis and morbidity rates.

Dis Colon Rectum. 2002-3

引用本文的文献

[1]
The Clinical Outcomes of Preoperative Self-Expandable Metal Stent Placement as Bridge to Surgery for Obstructive Colorectal Cancer.

Cancer Rep (Hoboken). 2025-6

[2]
An evaluation of the effectiveness and safety of endoscopic colon stenting in the treatment of obstructive left colon cancer: a systematic review and meta-analysis.

Langenbecks Arch Surg. 2025-6-4

[3]
Risk factors for postoperative anastomotic leakage in obstructive left colonic carcinoma.

Updates Surg. 2025-5-13

[4]
Transforming outcomes: the pivotal role of self-expanding metal stents in right- and left-sided malignant colorectal obstructions-bridge to surgery: a comprehensive review and meta-analysis.

Clin Endosc. 2025-3

[5]
Self-Expandable Metal Stents for Obstructing Colon Cancer and Extracolonic Cancer: A Review of Latest Evidence.

Cancers (Basel). 2024-12-30

[6]
Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment.

Ann Coloproctol. 2024-4

[7]
Management of obstructed colorectal carcinoma in an emergency setting: An update.

World J Gastrointest Oncol. 2024-3-15

[8]
Colon stenting as a bridge to surgery in obstructive colorectal cancer management.

Clin Endosc. 2024-7

[9]
Which treatment strategy is optimal for acute left-sided malignant colonic obstruction? A Bayesian meta-analysis.

Int J Colorectal Dis. 2023-8-17

[10]
Nomogram for predicting the probability of permanent stoma in patients with acute obstructive colorectal cancer.

Langenbecks Arch Surg. 2023-3-15

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