Gastroenterology Department, Centro Hospitalar São João, Porto, Portugal.
Gastroenterology Department, Centro Hospitalar São João, Porto, Portugal.
Dig Liver Dis. 2019 Mar;51(3):364-372. doi: 10.1016/j.dld.2018.11.006. Epub 2018 Nov 20.
OBJECTIVE: Compare efficacy, safety and long-term outcomes of bridge-to-surgery and emergency surgery in acute malignant colorectal obstruction. METHODS: Retrospective study of 94 consecutive patients with left-sided acute malignant colorectal obstruction treated with curative intent between 2010-2017. RESULTS: 48 patients underwent stent placement and 46 underwent emergency surgery. Technical and clinical success were 100% and 87%. Laparoscopy and one-staged operation were more frequent in bridge-to-surgery (44% vs 2%, p < 0.001; 73% vs 30%, p < 0.001). Fewer permanent stomas were created in bridge-to-surgery (15% vs 35%, p = 0.013). Overall morbidity was 36%. Immediate and post-procedure stent related-complications occurred in 6% and 13%; surgery-related complications occurred in 28% (bridge-to-surgery: 15% vs emergency surgery: 41%, p = 0.004). No differences were found regarding tumor recurrence, recurrence-free survival and overall survival. R1 resection (HR 47.2, CI:4.1-543.7), number of lymph nodes harvested (HR 0.9 CI:0.8-0.99) and adjuvant therapy (HR 0.1 CI:0.01-0.9) predicted recurrence-free survival; pTMN stage IV (HR 7.3, CI:1.1-47.6), number of lymph nodes harvested (HR 0.90, CI:0.8-0.97), adjuvant therapy (HR 0.1, CI:0.02-0.4) and surgery-related complications (HR 5.3, CI:1.02-27.3) influenced overall survival. CONCLUSION: Stent placement has a high success, similarly to emergency surgery, being associated with higher primary anastomosis and lower stoma rates. Tumor recurrence rate, recurrence-free survival and overall survival were comparable between groups; surgery-related complications influenced overall survival.
目的:比较桥接手术与急诊手术治疗急性恶性结直肠梗阻的疗效、安全性和长期结果。 方法:回顾性分析 2010 年至 2017 年间接受根治性治疗的 94 例左侧急性恶性结直肠梗阻患者。 结果:48 例患者行支架置入术,46 例行急诊手术。技术和临床成功率均为 100%和 87%。桥接手术组腹腔镜和一期手术更为常见(44%比 2%,p<0.001;73%比 30%,p<0.001)。桥接手术组永久性造口更少(15%比 35%,p=0.013)。总并发症发生率为 36%。即刻和术后支架相关并发症发生率分别为 6%和 13%;手术相关并发症发生率分别为 28%(桥接手术组:15%比急诊手术组:41%,p=0.004)。两组肿瘤复发、无复发生存率和总生存率无差异。R1 切除(HR 47.2,CI:4.1-543.7)、淋巴结清扫数目(HR 0.9 CI:0.8-0.99)和辅助治疗(HR 0.1 CI:0.01-0.9)预测无复发生存率;pTMN 分期 IV(HR 7.3,CI:1.1-47.6)、淋巴结清扫数目(HR 0.90,CI:0.8-0.97)、辅助治疗(HR 0.1,CI:0.02-0.4)和手术相关并发症(HR 5.3,CI:1.02-27.3)影响总生存率。 结论:支架置入术成功率高,与急诊手术相似,与更高的一期吻合率和更低的造口率相关。两组肿瘤复发率、无复发生存率和总生存率相当;手术相关并发症影响总生存率。
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