检测早产儿脑损伤患者血清褪黑素和 SBDPs 的临床意义。
Clinical significance of detecting serum melatonin and SBDPs in brain injury in preterm infants.
机构信息
Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
出版信息
Pediatr Neonatol. 2019 Aug;60(4):435-440. doi: 10.1016/j.pedneo.2018.11.005. Epub 2018 Nov 25.
BACKGROUND
To investigate the clinical values of serum melatonin and αII spectrin cleavage products (SBDPs) in assessing the severity of brain injury in preterm infants.
METHODS
Sixty-four premature infants in total were selected and classified into the brain injury group (BI, n = 30) and the non-brain injury group (CON, n = 34) according to cranial imaging examination. The serum melatonin and SBDPs were detected by ELISA. All the preterm infants were received NBNA testing at 40 weeks of corrected gestational age.
RESULTS
The levels of melatonin and SBDPs in the BI group were significantly higher than the CON group (p < 0.05) and the levels in the infants with severe brain injury were significantly higher than those with mild brain injury (p < 0.05), as well as exhibiting a negative correlation with the NBNA score at 40 weeks of corrected gestational age (p < 0.05).
CONCLUSIONS
Detecting melatonin and SBDPs has clinical value in diagnosing and assessing the severity of brain injury in preterm infants.
背景
探讨血清褪黑素和αII spectrin 裂解产物（SBDPs）在评估早产儿脑损伤严重程度中的临床价值。
方法
选取 64 例早产儿，根据头颅影像学检查分为脑损伤组（BI，n=30）和非脑损伤组（CON，n=34）。采用 ELISA 法检测血清褪黑素和 SBDPs。所有早产儿均在纠正胎龄 40 周时进行 NBNA 测试。
结果
BI 组的褪黑素和 SBDPs 水平明显高于 CON 组（p<0.05），重度脑损伤患儿的水平明显高于轻度脑损伤患儿（p<0.05），且与纠正胎龄 40 周时的 NBNA 评分呈负相关（p<0.05）。
结论
检测褪黑素和 SBDPs 对诊断和评估早产儿脑损伤严重程度具有临床价值。
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