Wang Tian Gong, Ye Meng
Medical School of Ningbo University, Ningbo 315211, China.
The Affiliated Hospital of Medical School of Ningbo University, Ningbo 315211, China.
Yi Chuan. 2018 Dec 20;40(12):1055-1065. doi: 10.16288/j.yczz.18-098.
Predominantly found in mRNA, m A methylation of RNA molecules regulates post-transcriptional gene expression without changing RNA sequence. m A methylation alters gene expression by modulating mRNA processing and metabolism, including alternative splicing, translation efficiency, and stability. Current research shows that m A methylation is involved in tumorigenesis, highlighting the importance of further study. However, traditional methods are not sensitive enough to detect the full patterns of m A methylation in the transcriptome. The development of new technologies, such as single-nucleotide detection combined with next generation sequencing, allows for the quick and accurate prediction and identification of m A methylation sites. In this review, we summarize the recent progress of m A in tumorigenesis and outline a new direction for both molecular pathology diagnosis and targeted therapy of tumor.
RNA分子的N6-甲基腺嘌呤（m⁶A）甲基化主要存在于信使核糖核酸（mRNA）中，可在不改变RNA序列的情况下调节转录后基因表达。m⁶A甲基化通过调控mRNA的加工和代谢来改变基因表达，包括可变剪接、翻译效率和稳定性。目前的研究表明，m⁶A甲基化参与肿瘤发生，凸显了进一步研究的重要性。然而，传统方法对检测转录组中m⁶A甲基化的完整模式不够敏感。新技术的发展，如结合新一代测序的单核苷酸检测，能够快速准确地预测和识别m⁶A甲基化位点。在本综述中，我们总结了m⁶A在肿瘤发生方面的最新进展，并概述了肿瘤分子病理学诊断和靶向治疗的新方向。
