Ogle K M, Kennedy B J
Department of Medicine, University of Minnesota Medical School, Minneapolis.
Am J Clin Oncol. 1988 Dec;11(6):663-5. doi: 10.1097/00000421-198812000-00015.
A case of immediate hypersensitivity to the chemotherapeutic agent etoposide is reported. The clinical details of the case and features of previously reported cases are outlined. An attempt to re-treat the patient with etoposide was unsuccessful despite vigorous premedication, in contrast to previous reports. The mechanism of hypersensitivity to this agent is still to be elucidated.
报告了一例对化疗药物依托泊苷立即发生超敏反应的病例。概述了该病例的临床细节以及先前报告病例的特征。与先前报告相反,尽管进行了积极的预处理,但再次尝试用依托泊苷治疗该患者仍未成功。对该药物超敏反应的机制仍有待阐明。