Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
Sci Rep. 2018 Dec 17;8(1):17897. doi: 10.1038/s41598-018-36115-7.
Early effective identification of high-risk patients for acute pulmonary embolism (APE) contributes to timely treatment. The pulmonary artery obstruction index (PAOI) in computed tomography angiography (CTA) is a semi-quantitative observation index, commonly used to evaluate the severity of a patient's condition. This study explores the ability of PAOI to assess the risk stratification of APE. Thirty patients with APE were analysed. They were classified according to the guidelines, and the PAOI and cardiovascular parameters were measured in CTA. The difference of PAOI between different risk stratification patients was compared, and the predictive value of the PAOI for high-risk stratification was evaluated by the receiver operating characteristic curve. The correlation between PAOI and cardiovascular parameters was also analysed by Spearman correlation analysis. The PAOI in low- and high-risk patients was (33.2 ± 18.6)% and (68.1 ± 11.8)% respectively, and the difference was statistically significant. The PAOI was strongly predictive for high-risk patients. The cut-off value was 52.5%, with a sensitivity of 100% and specificity of 81.0%. The PAOI was correlated with the main cardiovascular parameters. We conclude that the PAOI in CTA is helpful for assessing risk stratification in patients with APE, which contributes to the selection of both the treatment plan and prognostic evaluation.
早期有效识别急性肺栓塞(APE)高危患者有助于及时治疗。CTA 中的肺动脉阻塞指数(PAOI)是一种半定量观察指标,常用于评估患者病情的严重程度。本研究探讨了 PAOI 评估 APE 风险分层的能力。分析了 30 例 APE 患者。根据指南进行分类,并在 CTA 中测量 PAOI 和心血管参数。比较不同风险分层患者的 PAOI 差异,并通过接收者操作特征曲线评估 PAOI 对高危分层的预测价值。还通过 Spearman 相关分析分析了 PAOI 与心血管参数之间的相关性。低危和高危患者的 PAOI 分别为(33.2±18.6)%和(68.1±11.8)%,差异具有统计学意义。PAOI 对高危患者具有较强的预测能力。截断值为 52.5%,灵敏度为 100%,特异性为 81.0%。PAOI 与主要心血管参数相关。我们得出结论,CTA 中的 PAOI 有助于评估 APE 患者的风险分层,有助于治疗方案的选择和预后评估。