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鼻咽癌中P38丝裂原活化蛋白激酶表达与临床分期的相关性

Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma.

作者信息

Farhat Farhat, Daulay Elvita Rahmi, Chrestella Jessy, Asnir Rizalina Arwinati, Yudhistira Ashri, Susilo Riko Radityatama

机构信息

Universitas Sumatera Utara Fakultas Kedokteran, Otorhynolaryngology Head and Neck Surgery Jl. Dr. T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia.

Universitas Sumatera Utara Fakultas Kedokteran, Radiology Medan, North Sumatera, Indonesia.

出版信息

Open Access Maced J Med Sci. 2018 Nov 19;6(11):1982-1985. doi: 10.3889/oamjms.2018.355. eCollection 2018 Nov 25.

DOI:10.3889/oamjms.2018.355
PMID:30559847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6290411/
Abstract

BACKGROUND

Nasopharyngeal carcinoma (NPC) is uncommon and usually diagnosed at the advanced stage. A subfamily of mitogen-activated protein kinase which is called p38 mitogen-activated protein kinase (MAPK) involved in response to stress, and plays an important role in cell regulation. There is a suggestion that p38 mitogen-activated protein kinase could be a potential biomarker to determine the clinical stage of nasopharyngeal carcinoma.

AIM

The aim of this study is for observing and analysing the correlation of p38 mitogen-activated protein kinase expression in regards to nasopharyngeal carcinoma patient's clinical stage.

METHODS

This study involved 126 nasopharyngeal carcinoma patients admitted to Haji Adam Malik General Hospital.

RESULTS

The result of this study indicates that nasopharyngeal carcinoma mostly found in the age group 41-60 years, male, non-keratinizing squamous cell carcinoma, and stage IV group. In immunohistochemistry evaluation, most of p38 mitogen-activated protein kinase overexpressed in non-keratinizing squamous cell carcinoma, T3-T4, N2-N3 and clinical stage III-IV. Spearman's test for categorical correlation yield p-value of < 0.001.

CONCLUSION

In conclusion, there is a significant correlation between p38 mitogen-activated protein kinase expression and the clinical stage of nasopharyngeal carcinoma.

摘要

背景

鼻咽癌并不常见，通常在晚期才被诊断出来。有丝分裂原活化蛋白激酶的一个亚家族，即p38有丝分裂原活化蛋白激酶（MAPK），参与应激反应，并在细胞调节中发挥重要作用。有研究表明，p38有丝分裂原活化蛋白激酶可能是确定鼻咽癌临床分期的潜在生物标志物。

目的

本研究的目的是观察和分析p38有丝分裂原活化蛋白激酶表达与鼻咽癌患者临床分期之间的相关性。

方法

本研究纳入了126例入住哈芝亚当马利克综合医院的鼻咽癌患者。

结果

本研究结果表明，鼻咽癌多见于41 - 60岁年龄组、男性、非角化鳞状细胞癌以及IV期组。在免疫组织化学评估中，大多数p38有丝分裂原活化蛋白激酶在非角化鳞状细胞癌、T3 - T4、N2 - N3以及临床III - IV期过度表达。Spearman分类相关性检验的p值< 0.001。

结论

总之，p38有丝分裂原活化蛋白激酶表达与鼻咽癌临床分期之间存在显著相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe49/6290411/99a3edaf99e8/OAMJMS-6-1982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe49/6290411/99a3edaf99e8/OAMJMS-6-1982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe49/6290411/99a3edaf99e8/OAMJMS-6-1982-g001.jpg

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