胰腺癌胰十二指肠切除术后拟似转移复发的韧带样型纤维瘤病
Desmoid Fibromatosis Mimicking Metastatic Recurrence After Pancreatectomy for Pancreatic Adenocarcinoma.
作者信息
Navin Patrick, Lehrke Heidi D, Schmitz John J, Truty Mark J, Moynagh Michael R
机构信息
Department of Radiology, Mayo Clinic, Rochester, MN.
Department of Pathology, Mayo Clinic, Rochester, MN.
出版信息
Mayo Clin Proc Innov Qual Outcomes. 2018 Sep 20;2(4):392-397. doi: 10.1016/j.mayocpiqo.2018.07.003. eCollection 2018 Dec.
Abstract
Desmoid fibromatosis is a rare, neoplastic tumor known for its aggressive local invasion and recurrence after surgery. Tumors can occur sporadically or associated with familial adenomatous polyposis. We present 3 cases of desmoid fibromatosis postpancreatectomy for pancreatic adenocarcinoma. All cases occurred within 3 years of diagnosis of pancreatic cancer, with subsequent extensive diagnostic work-up to rule out metastatic disease. No relationship between pancreatic cancer and desmoid fibromatosis is documented in the literature, with a postulated connection via mutations on the Wnt/APC/Beta-catenin pathway.
摘要
韧带样纤维瘤病是一种罕见的肿瘤，以其侵袭性局部浸润及术后复发而闻名。肿瘤可散发性发生或与家族性腺瘤性息肉病相关。我们报告了3例胰腺癌胰十二指肠切除术后发生韧带样纤维瘤病的病例。所有病例均在胰腺癌诊断后3年内发生，随后进行了广泛的诊断性检查以排除转移性疾病。文献中未记载胰腺癌与韧带样纤维瘤病之间的关系，推测通过Wnt/APC/β-连环蛋白途径的突变存在联系。
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