Parker A C, Stuart A E
Scand J Haematol. 1978 Feb;20(2):129-40. doi: 10.1111/j.1600-0609.1978.tb02437.x.
Leucocytes which form rosettes with himologous erythrocytes in auto-immune haemolytic anaemia, infectious mononucleosis and following the stimulation of lymphocyte cultures with PHA have been studied by electron microscopy. The studies showed that the predominant homologous rosette forming cell was lymphocytic and the evidence favoured the conclusion that they were non-immune in nature. This identification does not classify the lymphocyte as thymus or bone marrow derived. Just under half (44%) of the total lymphocytic RFC had perinuclear microfilaments and limited clearing of the plasma of ribosomes close to the cell membrane. These features are consistent with activated T lymphocytes. The remainder of the lymphocytic RFC had no features which allowed their identification as T or B cells. The form of contact between lymphocytic RFC and erythrocyte was mainly of a pointlike nature, with little deformation or invasion of the attached erythrocytes. Monocytes were the only other type of cell encountered with any frequency. Their prime distinguishing feature was the deformation of attached red cells which they caused.
在自身免疫性溶血性贫血、传染性单核细胞增多症以及用植物血凝素刺激淋巴细胞培养后，对与同源红细胞形成玫瑰花结的白细胞进行了电子显微镜研究。研究表明，主要的同源玫瑰花结形成细胞是淋巴细胞，证据支持它们本质上是非免疫性的这一结论。这种识别并没有将淋巴细胞分类为源自胸腺或骨髓。在总的淋巴细胞玫瑰花结形成细胞（RFC）中，略少于一半（44%）的细胞有核周微丝，且靠近细胞膜的核糖体胞浆有有限的清除。这些特征与活化的T淋巴细胞一致。其余的淋巴细胞玫瑰花结形成细胞没有可将它们识别为T细胞或B细胞的特征。淋巴细胞玫瑰花结形成细胞与红细胞之间的接触形式主要是点状的，附着的红细胞很少有变形或被侵入。单核细胞是唯一经常遇到的其他类型细胞。它们的主要区别特征是它们引起的附着红细胞的变形。
