Hahn von Dorsche H, Reiher H, Hahn H J
Institute of Anatomy, School of Medicine, Ernst-Moritz-Arndt-University Greifswald, GDR.
Anat Anz. 1988;166(1-5):69-76.
The study included morphometric examination and biochemical investigation of 41 human pancreata taken from 14th to 26th weeks of fetal development. 3 phases of development were observed. Phase I (weeks 14 to 16) is characterized by the presence of mainly islet buds. They were originated from the ducts and are vascularized during week 16. During phase II (17th to 20th weeks) the islet buds were detached from the ducts and they formed new mantled islets with the B cells in the centre. Non-B cells are situated on the periphery around the insulin producing cells. Phase III lasts from week 21 to week 26. During this phase B cells and non-B cells become more irregularly positioned within the islet, a cytology, which is similar approximating that of as also found in adult human islets. The changes of islet structure during pancreatic development are accompanied by other typical phenomena: Islet size increases during phases I and II, but decreases again during phase III. The proportion of isolated B cells outside of the islets varies during this stage of fetal development, but they generally account for about 15% of the total islet organ. This should be taken into account when assessing the islet function De Pablo et al. (1985) on a morphological basis.
该研究包括对41例取自胎儿发育第14至26周的人类胰腺进行形态学检查和生化研究。观察到3个发育阶段。第一阶段（第14至16周）的特征主要是存在胰岛芽。它们起源于导管，并在第16周时血管化。在第二阶段（第17至20周），胰岛芽与导管分离，形成新的有被膜胰岛，中心为B细胞。非B细胞位于产生胰岛素细胞周围的外周。第三阶段从第21周持续到第26周。在此阶段，B细胞和非B细胞在胰岛内的定位变得更加不规则，这种细胞学特征与成人胰岛中的情况相似。胰腺发育过程中胰岛结构的变化伴随着其他典型现象：胰岛大小在第一阶段和第二阶段增加，但在第三阶段再次减小。在胎儿发育的这个阶段，胰岛外孤立B细胞的比例有所变化，但它们通常占胰岛器官总数的约15%。在基于形态学评估胰岛功能时应考虑到这一点（德帕布罗等人，1985年）。
