Yamamoto K, Miwa T, Ueno R, Hayaishi O
Hayaishi Bioinformation Transfer Project, Research Development Corporation of Japan, Osaka Medical College, Takatsuki.
Biochem Biophys Res Commun. 1988 Oct 31;156(2):882-8. doi: 10.1016/s0006-291x(88)80926-4.
We used primary cultures of rat brain astroglial cells in order to investigate the interrelationship between PGD2 and other sleep-promoting substances such as muramyl dipeptide (MDP), lipopolysaccharide (LPS), delta-sleep-inducing peptide (DSIP), uridine, and interleukin 1 (IL-1). A large amount of PGD2 was released into the culture medium by stimulation with MDP, LPS, and IL-1 but DSIP and uridine failed to stimulate such release. These results suggest that PGD2 may be part of the series of biochemical steps involved in induction of sleep by MDP, LPS, and IL-1.
为了研究前列腺素D2（PGD2）与其他促睡眠物质如胞壁酰二肽（MDP）、脂多糖（LPS）、δ-睡眠诱导肽（DSIP）、尿苷和白细胞介素1（IL-1）之间的相互关系，我们使用了大鼠脑星形胶质细胞的原代培养物。通过MDP、LPS和IL-1刺激，大量PGD2释放到培养基中，但DSIP和尿苷未能刺激这种释放。这些结果表明，PGD2可能是MDP、LPS和IL-1诱导睡眠所涉及的一系列生化步骤的一部分。
