Huang Anqi, Zhang Lili, Li Dongmei, Liu Yidong, Yan Hailong, Li Wenjun
Department of Medicinal Chemistry, School of Pharmacy , Qingdao University , Qingdao , Shandong 266021 , P. R. China.
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences , Chongqing University , Chongqing 401331 , P. R. China.
Org Lett. 2019 Jan 4;21(1):95-99. doi: 10.1021/acs.orglett.8b03492. Epub 2018 Dec 19.
An organocatalytic enantioselective method for the synthesis of multiple stereoisomers bearing E, Z configurations, stereogenic carbon centers, and axially chiral styrenes is reported. The method enabled the rapid construction of a series of stereochemical complexity products with excellent E, Z selectivity, diastereoselectivity (>20:1 dr), and enantioselectivity (up to 96% ee). This method provides an efficient and concise synthesis route of multiple stereoisomers with a wide range of potential applications in organic synthesis.
报道了一种用于合成具有E、Z构型、手性碳中心和轴手性苯乙烯的多种立体异构体的有机催化对映选择性方法。该方法能够快速构建一系列具有优异的E、Z选择性、非对映选择性（>20:1 dr）和对映选择性（高达96% ee）的立体化学复杂产物。该方法为多种立体异构体提供了一种高效简洁的合成路线，在有机合成中具有广泛的潜在应用。
