Worth D, Harvey J, Brown J, Lee M
Department of Medicine, General Infirmary, Leeds, UK.
Eur J Clin Pharmacol. 1988;35(2):137-41. doi: 10.1007/BF00609242.
L-dopa 7 micrograms.kg-1.min-1 was given intravenously over 2 h to six healthy subjects, controlled by an infusion of saline on a separate occasion, with measurement of plasma renin activity (PRA), urinary sodium and potassium excretion, effective renal plasma flow (ERPF), glomerular filtration rate (GFR), blood pressure, and pulse rate. Mean PRA fell by 50% following L-dopa, which was significantly different from the slight rise which occurred after saline infusion. There was a significant increase in urinary sodium excretion and effective renal plasma flow on infusion of L-dopa. Mean diastolic blood pressure fell during L-dopa infusion, in contrast to the slight increase which occurred during the control study. These observations confirm the anticipated renal dopaminergic effects of L-dopa and also suggest a dopaminergic influence on renin release in man.
以7微克·千克⁻¹·分钟⁻¹的剂量将左旋多巴静脉输注给6名健康受试者，持续2小时，在另一个单独的场合通过输注生理盐水进行对照，并测量血浆肾素活性（PRA）、尿钠和钾排泄、有效肾血浆流量（ERPF）、肾小球滤过率（GFR）、血压和脉搏率。左旋多巴给药后平均PRA下降了50%，这与输注生理盐水后出现的轻微升高有显著差异。输注左旋多巴后尿钠排泄和有效肾血浆流量显著增加。与对照研究期间出现的轻微升高相反，左旋多巴输注期间平均舒张压下降。这些观察结果证实了左旋多巴预期的肾多巴胺能作用，也提示了多巴胺能对人体肾素释放的影响。
