Maclaren N K
Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610.
Diabetes. 1988 Dec;37(12):1591-4. doi: 10.2337/diab.37.12.1591.
Insulin-dependent diabetes remains a serious disease replete with life-threatening complications. The onset of the disease is becoming increasingly predictable through the detection of its associated autoantibodies. The natural history of pathogenic events is attenuated in those with adult onset over that seen in infants and children. Immunosuppression therapies in newly diagnosed patients have been shown to induce remissions, whereas various intervention strategies in rodent models (BB rats and nonobese diabetic mice) can delay and even prevent the onset of diabetes. The stage is set for serious consideration of intervention trials to delay the clinical disease in humans.
胰岛素依赖型糖尿病仍然是一种严重的疾病，充满了危及生命的并发症。通过检测其相关自身抗体，该疾病的发病越来越具有可预测性。与婴儿和儿童相比，成年发病者致病事件的自然病程有所减轻。新诊断患者的免疫抑制疗法已被证明可诱导缓解，而啮齿动物模型（BB大鼠和非肥胖糖尿病小鼠）中的各种干预策略可以延缓甚至预防糖尿病的发病。现在是认真考虑进行干预试验以延缓人类临床疾病的时候了。
