过氧化物还原酶的mRNA表达在肺癌中的预后作用。
Prognostic roles of mRNA expression of peroxiredoxins in lung cancer.
作者信息
Chen Liangyuan, Huang Chunli, Yang Xiaojun, Zhang Qiuqin, Chen Falin
机构信息
Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, People's Republic of China,
Department of Clinical Laboratory, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, People's Republic of China,
出版信息
Onco Targets Ther. 2018 Nov 27;11:8381-8388. doi: 10.2147/OTT.S181314. eCollection 2018.
BACKGROUND
The peroxiredoxin (PRDX) protein family is involved in cancer cell invasion and metastasis, but its prognostic value in lung cancer remain elusive.
METHODS
In this report, we accessed the overall survival (OS) of each individual mRNA expression through the Kaplan-Meier plotter (KM plotter) database, in which updated gene expression data and survival information include a total of 1,926 lung cancer patients.
RESULTS
Our results indicated that and mRNA expressions were associated with improved OS in all lung cancer patients especially in lung adenocarcinoma patients, whereas and mRNA expressions were associated with poor OS in all lung cancer patients. In addition, the prognostic value of PRDXs in the different clinicopathological features according to smoking status, pathological grades, clinical stages, and chemotherapeutic treatment of lung cancer patients was further assessed in the KM plotter database by the multivariate cox regression analysis.
CONCLUSION
Our finding will elucidate the prognostic role of PRDXs in lung cancer and might promote development of PRDX-targeted inhibitors for the treatment of lung cancer.
背景
过氧化物酶（PRDX）蛋白家族参与癌细胞的侵袭和转移，但其在肺癌中的预后价值仍不清楚。
方法
在本报告中，我们通过Kaplan-Meier绘图仪（KM绘图仪）数据库获取了每个个体mRNA表达的总生存期（OS），其中更新后的基因表达数据和生存信息共纳入了1926例肺癌患者。
结果
我们的结果表明，[具体基因]和[具体基因]的mRNA表达与所有肺癌患者尤其是肺腺癌患者的OS改善相关，而[具体基因]和[具体基因]的mRNA表达与所有肺癌患者的OS不良相关。此外，通过多变量cox回归分析在KM绘图仪数据库中进一步评估了PRDXs在根据吸烟状态、病理分级、临床分期和肺癌患者化疗治疗的不同临床病理特征中的预后价值。
结论
我们的发现将阐明PRDXs在肺癌中的预后作用，并可能促进开发针对PRDX的抑制剂用于治疗肺癌。
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