Kwang-il, Kim, MD, PhD, Professor, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Kyeongi-do, 13620, Republic of Korea. E-mail:
J Nutr Health Aging. 2019;23(1):79-83. doi: 10.1007/s12603-018-1115-4.
Sarcopenia, defined as loss of skeletal muscle mass and function with age, is an important health issue in aging society. We tried to investigate the relationship between blood pressure variability and skeletal muscle mass in nation-wide large population cohort. This cross-sectional study was based on data acquired in the Korea National Health and Nutrition Examination Survey (KNHANES), conducted from 2009 to 2011 by the Korean Centers for Disease Control and Prevention. We included 14,481 participants (age ≥ 20 years, male 6,302) for the analysis who had both blood pressure and whole-body dual energy X-ray absorptiometry (DXA) scan data. As an intra-individual within-visit blood pressure variability index, we calculated standard deviation (SD), coefficient of variation (CV), and maximum minus minimum BP difference (MMD) of systolic and diastolic blood pressure, which was measured 3 times. Appendicular skeletal muscle mass (ASM) was the sum of lean masses of both arms and legs. We adjusted ASM by body mass index. Significant inverse relationship was observed between blood pressure variability index (SD, CV, and MMD) and adjusted ASM. Blood pressure variability index were significantly higher in the lowest ASM quintile group both in male and female participants (p<0.001). In multivariate analysis, blood pressure variability index were significantly associated with ASM, even after adjusting confounding factors (p<0.001). In conclusion, hemodynamic influence may play an important role in the development of sarcopenia.
肌肉减少症是一种随年龄增长而发生的骨骼肌质量和功能丧失的疾病，是老龄化社会中的一个重要健康问题。我们试图在全国范围内的大型人群队列中研究血压变异性与骨骼肌质量之间的关系。这项横断面研究基于韩国疾病控制与预防中心（KCDC）于 2009 年至 2011 年进行的韩国国家健康和营养检查调查（KNHANES）的数据。我们纳入了 14481 名参与者（年龄≥20 岁，男性 6302 名）进行分析，这些参与者均有血压和全身双能 X 射线吸收法（DXA）扫描数据。作为个体内访间血压变异性指数，我们计算了收缩压和舒张压的标准差（SD）、变异系数（CV）和最大减最小血压差值（MMD），这些值均测量了 3 次。四肢骨骼肌质量（ASM）是手臂和腿部瘦质量的总和。我们通过体重指数调整了 ASM。血压变异性指数（SD、CV 和 MMD）与调整后的 ASM 呈显著负相关。在男性和女性参与者中，ASM 最低五分位数组的血压变异性指数均显著较高（p<0.001）。在多变量分析中，即使在调整混杂因素后，血压变异性指数仍与 ASM 显著相关（p<0.001）。总之，血流动力学的影响可能在肌肉减少症的发生中起重要作用。
