Kato Noriko, Masuda Yoichiro, Oki Kotaro, Iwaki Hisaharu, Tsuneoka Hiroshi
Department of Ophthalmology, School of Medicine, The Jikei University, 3-25-8 Nishishinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Oki Eye Surgery Center, Tokyo, Japan.
Jpn J Ophthalmol. 2019 Mar;63(2):221-228. doi: 10.1007/s10384-018-00646-3. Epub 2018 Dec 19.
To evaluate the effects of irrigation dynamic pressure-assisted hydrodissection (irrigation-hydro: iH) on intraocular pressure (IOP) and the posterior chamber-anterior hyaloid membrane (PC-AHM) barrier in porcine eyes.
Experimental.
In Experiment 1, IOP was recorded while irrigating the anterior chamber (AC), during iH, and during phacoemulsification and aspiration in 20 porcine eyes using bottle heights of 50, 70, and 90 cm. Under the same conditions, IOP was recorded during conventional manual cortical cleaving hydrodissection (manual hydro: mH) in 20 porcine eyes. In Experiment 2, after iH, ACs were perfused for 5 seconds with balanced salt solution containing 1.0-μm fluorescein beads in 20 porcine eyes using bottle heights of 70, 118, and 169 cm. PC-AHM barrier staining grade was evaluated by the Miyake-Apple view.
iH proved successful in all cases. In Experiment 1, IOP during iH was relatively stable and peak IOP was below the baseline bottle height-dependent pressure. No eyes showed a peak IOP > 75 mmHg during iH, but 8 eyes showed a peak IOP > 75 mmHg during mH. In Experiment 2, neither AHT nor ruptured capsules were observed at any bottle height.
Unlike mH, IOP during iH was relatively stable without any high peak IOP. Thus, iH offers a simple technique for reducing peak IOP and avoiding disturbance of the PC-AHM barrier.
评估灌注动态压力辅助水分离术(灌注-水分离:iH)对猪眼眼压(IOP)及后房-前玻璃体膜(PC-AHM)屏障的影响。
实验性研究。
在实验1中,使用50、70和90厘米的瓶高,对20只猪眼在前房灌注、iH期间以及超声乳化吸除过程中记录眼压。在相同条件下,对20只猪眼进行传统手动皮质劈开式水分离术(手动水分离:mH)时记录眼压。在实验2中,iH后,使用70、118和169厘米的瓶高,对20只猪眼的前房用含1.0微米荧光素珠的平衡盐溶液灌注5秒。通过三浦-苹果视图评估PC-AHM屏障染色分级。
所有病例中iH均成功。在实验1中,iH期间眼压相对稳定,眼压峰值低于基线瓶高相关压力。iH期间没有眼睛的眼压峰值>75 mmHg,但mH期间有8只眼睛的眼压峰值>75 mmHg。在实验2中,在任何瓶高下均未观察到高眼压或囊膜破裂。
与mH不同,iH期间眼压相对稳定,无任何高眼压峰值。因此,iH提供了一种降低眼压峰值并避免干扰PC-AHM屏障的简单技术。