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巴西南部的围孕期叶酸补充:我们为何没有做对?

Periconceptional folic acid supplementation in Southern Brazil: Why are not we doing it right?

机构信息

Graduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brazil.

Graduation in Nursing, UFCSPA, Porto Alegre, Brazil.

出版信息

Am J Med Genet A. 2019 Jan;179(1):20-28. doi: 10.1002/ajmg.a.60699. Epub 2018 Dec 19.

DOI:10.1002/ajmg.a.60699
PMID:30569628
Abstract

Several countries, as Brazil, have public policies for periconceptional folic acid supplementation (FAS) in order to prevent unfavorable outcomes. Our aim was to evaluate the FAS situation in a public reference hospital from Southern Brazil. This study included all mothers who had children born at the Hospital Materno Infantil Presidente Vargas, RS, Brazil, in a 1-year period. Data collection was conducted through interviews with application of a clinical protocol and analysis of the patients' records. FAS was defined as the use of folic acid in any period of the periconceptional period, irrespective of the duration and amount. We also classified those mothers who correctly followed the national recommendation proposed by the Health Ministry of Brazil. The sample consisted of 765 mothers evaluated soon after childbirth. Their ages ranged from 12 to 45 years (mean 25.2 years). The overall level of FAS was 51.5%, and the use according to the national recommendation occurred in only 1.6%. Factors associated with non-FAS consisted of lower maternal age (p = .009) and maternal schooling (p = .023), higher number of pregnancies (p = .003), fewer prenatal visits (p = .050) and later prenatal care onset (p = .037). Periconceptional FAS in our midst seems to be very far from the ideal goal. Susceptible groups appeared to be mothers who were younger, less educated, multiparous, and had inadequate prenatal care. We believe that efforts of education and awareness should be especially targeted for these groups. These recommendations should also be strengthened among those who prescribe the FAS.

摘要

一些国家,如巴西,制定了围孕期叶酸补充(FAS)的公共政策,以预防不良结局。我们的目的是评估巴西南部一家公立参考医院的 FAS 情况。这项研究包括在巴西总统瓦尔加斯母婴医院出生的所有母亲,为期一年。数据收集是通过应用临床方案对母亲进行访谈和分析患者记录进行的。FAS 的定义是在围孕期的任何时期使用叶酸,无论持续时间和数量如何。我们还根据巴西卫生部提出的国家建议对正确遵循建议的母亲进行了分类。该样本由 765 名分娩后不久接受评估的母亲组成。她们的年龄从 12 岁到 45 岁不等(平均 25.2 岁)。FAS 的总体水平为 51.5%,而仅按照国家建议使用的比例为 1.6%。与未进行 FAS 相关的因素包括母亲年龄较小(p = 0.009)和受教育程度较低(p = 0.023)、妊娠次数较多(p = 0.003)、产前检查次数较少(p = 0.050)和产前护理开始较晚(p = 0.037)。我们中间的围孕期 FAS 似乎远未达到理想目标。弱势群体似乎是年龄较小、受教育程度较低、多产和产前保健不足的母亲。我们认为,应该特别针对这些群体开展教育和提高认识的工作。这些建议也应该在开处方 FAS 的人群中得到加强。

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Nutrients. 2025 Aug 26;17(17):2752. doi: 10.3390/nu17172752.
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Investigating continuation of folic acid supplementation during peri-conceptional period: a community-based cross-sectional study.调查围孕期叶酸补充的延续情况:一项基于社区的横断面研究。
Reprod Health. 2023 Feb 20;20(1):34. doi: 10.1186/s12978-023-01564-5.
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Periconceptional Folic Acid Supplementation and the Risk of Spontaneous Abortion among Women Who Prepared to Conceive: Impact of Supplementation Initiation Timing.
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Nutrients. 2020 Jul 29;12(8):2264. doi: 10.3390/nu12082264.