1 Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, Strasbourg, France.
2 EA 3072, FMTS (Fédération de Médecine Translationnelle de l'Université de Strasbourg), Faculté de Médecine, Université de Strasbourg, Strasbourg, France.
Antioxid Redox Signal. 2019 Aug 10;31(5):420-426. doi: 10.1089/ars.2018.7689. Epub 2019 Jan 31.
Reactive oxygen species (ROS) are central bioenergetic markers linked to aortic stenosis (AS) development and severity. We sought to evaluate the time course and impact of ROS assessed by plasmatic superoxide anion (SA) among patients undergoing transcatheter aortic valve replacement (TAVR). Among 106 patients, SA significantly decreased after TAVR. Dropped values were measured 10 min after TAVR (0.590 ± 0.181 0.648 ± 0.193; < 0.001) and persistent at 3 days (0.611 ± 0.0.228 0.646 ± 0.199; = 0.033) and 30 days follow-up (0.572 ± 0.207 0.639 ± 0.199; = 0.005). Increased baseline SA (>75 percentile) was continuously associated with higher postprocedural SA values 10 min after valve expansion ( < 0.001), at 3 days ( < 0.001) and 30 days ( < 0.001). Higher baseline SA was linked to higher inflammatory response assessed by higher C-reactive protein values at day 1 and day 3. The composite endpoint of all-cause mortality and/or stroke and/or pacemaker implantation and/or significant paravalvular aortic regurgitation ≥mild at 30 days did not differ significantly according to SA baseline values ( = 0.055). This is the first report identifying a decrease in oxidative stress level after TAVR. Our observation leads to the hypothesis that oxidative stress biomarkers may survive the journey from bench to bedside in AS and TAVR and become new biomarkers with both diagnostic and prognostic values. 31, 420-426.
活性氧（ROS）是与主动脉瓣狭窄（AS）发展和严重程度相关的核心生物能量标志物。我们旨在评估经导管主动脉瓣置换术（TAVR）后患者血浆超氧阴离子（SA）评估的时间过程和影响。在 106 例患者中，TAVR 后 SA 显著降低。TAVR 后 10 分钟测量的下降值（0.590±0.181 0.648±0.193； <0.001），并在 3 天（0.611±0.0.228 0.646±0.199； =0.033）和 30 天随访时持续存在（0.572±0.207 0.639±0.199； =0.005）。较高的基线 SA（>75 百分位数）与瓣膜扩张后 10 分钟的术后 SA 值较高持续相关（ <0.001），3 天（ <0.001）和 30 天（ <0.001）。较高的基线 SA 与较高的炎症反应相关，表现为第 1 天和第 3 天的 C 反应蛋白值较高。30 天时全因死亡率和/或卒中和/或起搏器植入和/或≥中度瓣周主动脉反流的复合终点，根据 SA 基线值无显著差异（ =0.055）。这是第一个报道 TAVR 后氧化应激水平降低的报告。我们的观察结果提出了一个假设，即氧化应激生物标志物可能在 AS 和 TAVR 从实验室到临床的过程中幸存下来，并成为具有诊断和预后价值的新生物标志物。31, 420-426.
