Department of Health Sciences, Faculty of Science, University of Mauritius , Réduit , Mauritius.
Department of Biology, Science Faculty, Selcuk University , Konya , Turkey.
Int J Environ Health Res. 2019 Dec;29(6):607-621. doi: 10.1080/09603123.2018.1558184. Epub 2018 Dec 20.
This study investigated into the phytochemical profile and biological properties of extracts (methanol and aqueous) of based on the antioxidant, enzyme inhibitory, and antibacterial activities. The aqueous extract exhibited higher antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), ferric reducing antioxidant power, cupric reducing antioxidant capacity, phosphomolybdenum, and metal chelating assays, compared to the methanol extract. In contrast, the methanol extract was the most effective inhibitor of acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase. The methanol extract also showed higher antibacterial activity with highest inhibition against (MIC = 6.25 mg/mL). The total phenolic content was higher in the aqueous extract while the methanol extract possessed higher total flavonoid content. A total of 28 and 18 compounds (belonging to polyphenols, flavonoids, terpenoids, and ester classes) were identified from the methanol and water extracts, respectively. These findings suggest that could be helpful in the management of oxidative stress-associated diseases including diabetes and neurodegenerative complications. ABTS: 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid; ACAE: acarbose equivalent; AChE: acetylcholinesterase; AD: Alzheimer's disease; BChE: butyrylcholinesterase; CUPRAC: cupric reducing antioxidant capacity; DPPH: 1,1-diphenyl-2-picrylhydrazyl; EDTAE: EDTA equivalent; FRAP: ferric reducing antioxidant power; GAE: gallic acid equivalent; GALAE: galatamine equivalent; HPLC: high performance liquid chromatography; KAE: kojic acid equivalent; RE: rutin equivalents; TE: trolox equivalent; TPC: total phenolic content; TFC: total flavonoid content.
这项研究调查了基于抗氧化、酶抑制和抗菌活性的 和 的提取物（甲醇和水）的植物化学特征和生物特性。与甲醇提取物相比，水提取物在 1,1-二苯基-2-苦基肼（DPPH）、2,2'-联氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）、铁还原抗氧化能力、铜还原抗氧化能力、磷钼酸盐和金属螯合测定中表现出更高的抗氧化活性。相比之下，甲醇提取物是乙酰胆碱酯酶、丁酰胆碱酯酶、酪氨酸酶、α-淀粉酶和α-葡萄糖苷酶的最有效抑制剂。甲醇提取物还显示出更高的抗菌活性，对 （MIC = 6.25 mg/mL）的抑制作用最强。水提取物中的总酚含量较高，而甲醇提取物中的总黄酮含量较高。从甲醇和水提取物中分别鉴定出 28 种和 18 种化合物（属于多酚、类黄酮、萜类和酯类）。这些发现表明， 可能有助于管理与氧化应激相关的疾病，包括糖尿病和神经退行性并发症。ABTS：2,2'-联氮双（3-乙基苯并噻唑啉-6-磺酸）；ACAE：阿卡波糖当量；AChE：乙酰胆碱酯酶；AD：阿尔茨海默病；BChE：丁酰胆碱酯酶；CUPRAC：铜还原抗氧化能力；DPPH：1,1-二苯基-2-苦基肼；EDTAE：EDTA 当量；FRAP：铁还原抗氧化能力；GAE：没食子酸当量；GALAE：加兰他敏当量；HPLC：高效液相色谱；KAE：曲酸当量；RE：芦丁当量；TE：trolox 当量；TPC：总酚含量；TFC：总黄酮含量。
