Zykov M B, Melekhova A M
Zh Vyssh Nerv Deiat Im I P Pavlova. 1978 Jan-Feb;28(1):92-7.
In experiments on rabbits a study was made of the influence of serotonin's precursor, 5-oxytriptophane (5-OTP), on trace processes in spike activity of neurones in the visual and sensorimotor cortical areas. Rhythmic light was used as a stimulus with a frequency of 2 or 5 per second. Administration of 5-OTP produced prolonged action of the trace processes, significant for 2 per second frequency and less pronounced for 5 per second frequency of the flashes. This property was possessed both by the neurones which increased their activity frequency and those which reduced it. It is assumed that the prolonging effect of 5-OTP is the consequence of its modulating influence on the brain activity, which is manifested in a selective potentiation of the functioning of a neuronal system with a relatively lower frequency of spontaneous firing.
在对兔子的实验中，研究了血清素的前体5-羟色氨酸（5-OTP）对视觉和感觉运动皮层区域神经元锋电位活动中的痕迹过程的影响。以每秒2次或5次的频率的节律性光作为刺激。给予5-OTP可使痕迹过程的作用延长，对于每秒2次的频率有显著影响，而对于每秒5次的闪光频率影响较小。增加其活动频率的神经元和降低其活动频率的神经元都具有这种特性。据推测，5-OTP的延长作用是其对大脑活动的调节影响的结果，这表现为对具有相对较低自发放电频率的神经元系统功能的选择性增强。
