Tham Ming S, Smyth Ian M
Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Wiley Interdiscip Rev Dev Biol. 2019 Mar;8(2):e338. doi: 10.1002/wdev.338. Epub 2018 Dec 20.
Kidneys are bilateral organs required to maintain homeostasis in the body through the regulation of fluid composition and the excretion of metabolic waste products. The initial steps in organ development are characterized by cellular interactions which regulate both the position and number of kidneys formed. Once established, further development is driven by orchestrated interactions between progenitor cell populations which serve to establish both nephrons-the functional unit of the organ which filters the blood-and the complex ramified collecting duct system which transports urine to the bladder. The delicate balance involved in these processes is reflected in the emerging family of genetic or environmental factors which, when perturbed, give rise to defects in organ development or function later in life. This article is categorized under: Vertebrate Organogenesis > From a Tubular Primordium: Branched Birth Defects > Organ Anomalies.
肾脏是成对的器官，通过调节体液成分和排泄代谢废物来维持体内的稳态。器官发育的初始阶段以细胞间相互作用为特征，这些相互作用调节所形成肾脏的位置和数量。一旦形成，进一步的发育由祖细胞群体之间精心编排的相互作用驱动，这些相互作用有助于建立肾单位——过滤血液的器官功能单位——以及将尿液输送到膀胱的复杂分支集合管系统。这些过程中涉及的微妙平衡反映在新出现的遗传或环境因素家族中，当这些因素受到干扰时，会在生命后期导致器官发育或功能缺陷。本文分类如下：脊椎动物器官发生>从管状原基开始：分支出生缺陷>器官异常。
