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下颌骨骨内黏液表皮样癌1例罕见病例报告及文献复习

An unusual case of intraosseous mucoepidermoid carcinoma of the mandible: A case report and literature review.

作者信息

Li Xiang, Wang Feng, Wang Yufan, Sun Shuai, Yang Hongyu

机构信息

Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province.

Graduate Department, Anhui Medical University, Hefei, Anhui Province, P.R. China.

出版信息

Medicine (Baltimore). 2018 Dec;97(51):e13691. doi: 10.1097/MD.0000000000013691.

Abstract

RATIONALE

Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy. Ectopic MEC can occur in any part of the body, however, only 2% to 4% of MEC could be detected in the jaw, which is named intraosseous mucoepidermoid carcinoma (IMC). IMC is usually a low-grade carcinoma. Uni- or multilocular radiographic lesions should be differential diagnosed with ameloblastoma, odontogenic cysts, and glandular odontogenic cyst (GOC). Radical surgery may prefer for a favorable prognosis. Whereas IMC can recur long after the operation, a long-term follow-up system should be implemented. Owing to its rarity and controversial issues, we report a case report and review the literature to discuss its clinical features, treatments, radiological, and histological characteristics.

PATIENT CONCERNS

The patient presented with a 2-month history of mild pain in the lower left posterior jaw without history of surgery or trauma to the mandible.

DIAGNOSES

Routine postoperative pathology showed that the mass was consistent with a mandibular mucoepidermoid carcinoma.

INTERVENTION

Radical surgery and digital mandibular reconstruction were performed.

OUTCOME

Postoperative imaging showed that the height of the mandible and the symmetry of the mandible were satisfactory. The patient was also satisfied with her appearance. Follow-up has been established.

LESSONS

Effective surgical treatment allows patients to have a favorable prognosis. A long-term follow-up system should be practiced, because local recurrences and regional metastasis could happen even after decades.

摘要

原理

黏液表皮样癌(MEC)是最常见的原发性涎腺恶性肿瘤。异位MEC可发生于身体的任何部位,然而,仅有2%至4%的MEC发生于颌骨,称为骨内黏液表皮样癌(IMC)。IMC通常为低级别癌。单房或多房的影像学病变应与成釉细胞瘤、牙源性囊肿及腺性牙源性囊肿(GOC)进行鉴别诊断。根治性手术可能有利于预后。鉴于IMC术后可能长期复发,应实施长期随访制度。由于其罕见性及存在争议的问题,我们报告一例病例并复习文献以探讨其临床特征、治疗方法、影像学及组织学特点。

患者情况

患者左下后牙区疼痛2个月,下颌无手术或外伤史。

诊断

术后常规病理显示肿物符合下颌黏液表皮样癌。

干预措施

实施根治性手术及数字化下颌骨重建。

结果

术后影像学检查显示下颌骨高度及对称性良好。患者对外观也很满意。已建立随访。

经验教训

有效的手术治疗可使患者获得良好预后。应实行长期随访制度,因为即使数十年后仍可能发生局部复发和区域转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdb/6320197/412e21503163/medi-97-e13691-g001.jpg

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