Mitsunaga M, Kashihara N, Okada K, Sasaki N, Nanba K
Dept. of Internal Medicine, Kure Kyosai Hospital.
Gan No Rinsho. 1988 Oct;34(12):1699-704.
From 1977 to 1984, 500 patients with thyroid disease (426 females and 74 males) were seen at the Kure Kyosai Hospital. Among them 6 patients (1 female and 5 males; all older than 50 y) were found to have a primary malignant lymphoma of the thyroid. Histologically, two were identified as being SNC, two were D-Mx, one was a D-L, and the last an IBL (plasmacytoid), according to the Working Formulation. Three patients manifesting a high grade malignancy died within 6 months after the diagnosis. Thyroid autoantibodies were detected in four patients, and, histologically, three of the four had chronic thyroiditis. The relationship between primary malignant lymphoma of the thyroid and chronic thyroiditis is discussed.
1977年至1984年期间，久留米共济医院共诊治了500例甲状腺疾病患者（女性426例，男性74例）。其中6例（1例女性和5例男性；均超过50岁）被发现患有原发性甲状腺恶性淋巴瘤。根据工作分类法，组织学上，2例被鉴定为弥漫性小无裂细胞型，2例为弥漫性混合细胞型，1例为弥漫性大细胞型，最后1例为免疫母细胞型（浆细胞样）。3例表现为高度恶性的患者在诊断后6个月内死亡。4例患者检测到甲状腺自身抗体，组织学检查发现其中3例患有慢性甲状腺炎。本文讨论了原发性甲状腺恶性淋巴瘤与慢性甲状腺炎之间的关系。
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