From the Departments of Radiology and Imaging Sciences (C.D.S., N.K.).
Pediatrics (R.C.C.).
AJNR Am J Neuroradiol. 2019 Feb;40(2):366-369. doi: 10.3174/ajnr.A5888. Epub 2018 Dec 20.
High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.
1 型神经纤维瘤病患者的高级别胶质瘤较为罕见,因此在脑病变的鉴别诊断中可能不会考虑到。在此,我们描述了 5 例 1 型神经纤维瘤病患儿;其中 4 例发生了各种类型的高级别胶质瘤。第 5 例患者的影像学特征提示为高级别病变,但组织学诊断为低级别胶质瘤。此处提供的病例和文献综述旨在提高对 1 型神经纤维瘤病患儿中高级别胶质瘤发生的认识,以及仅凭影像学特征预测高级别恶性肿瘤的能力有限。