Otani Tomoyuki, Hatakeyama Kinta, Ohtani Emi, Nakayama Susumu, Fujimoto Takashi, Ohbayashi Chiho
Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan.
Department of Diagnostic Pathology, Minami-Nara General Medical Center, Yoshino, Japan.
Clin Med Insights Pathol. 2018 Dec 6;11:1179555718815918. doi: 10.1177/1179555718815918. eCollection 2018.
Perineurioma is a mesenchymal neoplasm best known in soft-tissue pathology. A colonic perineurioma is a relatively recently described entity and sometimes encountered in specimens from the large intestine, especially distal colon. Without its recognition, a perineurioma can be misdiagnosed as other more common gastrointestinal spindle cell neoplasms. Here, we describe a case of colonic perineurioma with polypoid growth extruding into the intestinal lumen. A woman in her seventh decade of life underwent a follow-up colonoscopy after an uneventful resection of a benign colonic polyp. A previously undetected 6-mm polyp was found in the sigmoid colon and was resected endoscopically. Microscopic examination of the lesion revealed a proliferation of bland spindle cells in the lamina propria mucosae, which were immunohistochemically positive for epithelial membrane antigen, claudin 1, and glucose transporter-1. A colonic perineurioma was diagnosed.
神经束膜瘤是一种间叶性肿瘤，在软组织病理学中最为人所知。结肠神经束膜瘤是一种相对较新描述的实体，有时在大肠标本中出现，尤其是在结肠远端。如果不能识别，神经束膜瘤可能会被误诊为其他更常见的胃肠道梭形细胞肿瘤。在此，我们描述一例具有息肉样生长并突入肠腔的结肠神经束膜瘤病例。一名70多岁的女性在顺利切除一个良性结肠息肉后接受了结肠镜随访。在乙状结肠发现了一个先前未检测到的6毫米息肉，并通过内镜切除。对病变进行显微镜检查发现黏膜固有层有温和的梭形细胞增生，这些细胞上皮膜抗原、紧密连接蛋白1和葡萄糖转运蛋白-1免疫组化呈阳性。诊断为结肠神经束膜瘤。
