炎症在妊娠期糖尿病与阻塞性睡眠呼吸暂停关联中的作用：一项初步研究。
The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: A pilot study.
作者信息
Bublitz M H, Carpenter M, Amin S, Okun M L, Millman R, De La Monte S M, Bourjeily G
机构信息
Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, USA.
Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, USA.
出版信息
Obstet Med. 2018 Dec;11(4):186-191. doi: 10.1177/1753495X18780095. Epub 2018 Jul 24.
BACKGROUND
Obstructive sleep apnea is associated with pregnancy complications including gestational diabetes. Mechanisms underlying the association between obstructive sleep apnea and gestational diabetes remain to be elucidated.
METHODS
Twenty-three participants with gestational diabetes underwent home sleep apnea testing. Obstructive sleep apnea was defined as an apnea hypopnea index > 5. Fasting morning blood samples were measured using multianalyte profiling (xMAP) multiplexed bead array immunoassay for Interleukin 6, tumor necrosis factor-alpha, and Interleukin 8.
RESULTS
Age, body mass index, and gestational age at enrollment were 31 + 4.4 years, 35.7 + 7.4 kg/m, and 28 ± 4 weeks, respectively. Participants were 52% Caucasian and 16% had obstructive sleep apnea. We observed positive correlations between apnea hypopnea index and Interleukin 6 (r = 0.62, = 0.005), Interleukin 8 (r = 0.56, = .56), and tumor necrosis factor-alpha (r = .58, = .009). Women with obstructive sleep apnea had higher levels of Interleukin 6 (F = 5.01, = .037) and Interleukin 8 (F = 6.33, = .021) vs. women without obstructive sleep apnea.
CONCLUSION
These preliminary results indicate that in women with gestational diabetes, apnea hypopnea index is associated with an elevated inflammatory profile.
背景
阻塞性睡眠呼吸暂停与包括妊娠期糖尿病在内的妊娠并发症相关。阻塞性睡眠呼吸暂停与妊娠期糖尿病之间关联的潜在机制仍有待阐明。
方法
23名患有妊娠期糖尿病的参与者接受了家庭睡眠呼吸暂停测试。阻塞性睡眠呼吸暂停定义为呼吸暂停低通气指数>5。使用多分析物谱分析（xMAP）多重微珠阵列免疫测定法测量空腹晨血样本中的白细胞介素6、肿瘤坏死因子-α和白细胞介素8。
结果
入组时的年龄、体重指数和孕周分别为31±4.4岁、35.7±7.4kg/m²和28±4周。参与者中52%为白种人，16%患有阻塞性睡眠呼吸暂停。我们观察到呼吸暂停低通气指数与白细胞介素6（r = 0.62，P = 0.005）、白细胞介素8（r = 0.56，P = 0.056）和肿瘤坏死因子-α（r = 0.58，P = 0.009）之间呈正相关。与没有阻塞性睡眠呼吸暂停的女性相比，患有阻塞性睡眠呼吸暂停的女性白细胞介素6（F = 5.01，P = 0.037）和白细胞介素8（F = 6.33，P = 0.021）水平更高。
结论
这些初步结果表明，在患有妊娠期糖尿病的女性中，呼吸暂停低通气指数与炎症水平升高相关。
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