Ghodrati Saeed, Shahabinezhad Zahra, SeyedAlinaghi SeyedAhmad
Shahid Beheshti University, Institute for Cognitive and Brain Sciences, Tehran, Iran.
Kharazmi University of Tehran, Department of Counselling, Tehran, Iran.
Infect Disord Drug Targets. 2019;19(3):297-303. doi: 10.2174/1871526519666181221123932.
With recent progress in the treatment of people living with HIV (PLWH) and their increased rate of survival, health-related quality of life (HRQoL) has become an important issue.
In the present study, we aimed to investigate the association of current CD4 cell count, baseline CD4 cell count, nadir CD4 cell count, and plasma viral load with health-related quality of life in PLWH.
Participants were 67 PLWH who were under the treatment of antiretroviral therapy (ART) in Imam Khomeini Hospital of Tehran, Iran in 2016. Participants were divided into the two groups with high and low levels of current CD4 cell count, baseline CD4 cell count, nadir CD4 cell count and plasma viral load. We used independent sample t-test for data analysis using SPSS 22 software.
Our results demonstrated that for current CD4 cell count, the group differences were significant for total scores of HRQoL (P=0.028), also in the components of physical functioning (P=0.032), role limitation due to physical health problems (P=0.006), and role limitation due to emotional problems (P=0.009). Our data analysis showed that for baseline CD4 cell count (P=0.62), nadir CD4 cell count (P=0.29), and viral load group (P=0.78), the differences were not significant for HRQoL.
Knowing the association between current CD4 count and health-related quality of life, adherence to ART might be a motivator for PLWH to enhance their health-related quality of life.
随着人类免疫缺陷病毒感染者（PLWH）治疗方面的最新进展以及其生存率的提高，健康相关生活质量（HRQoL）已成为一个重要问题。
在本研究中，我们旨在调查当前CD4细胞计数、基线CD4细胞计数、最低CD4细胞计数和血浆病毒载量与PLWH健康相关生活质量之间的关联。
参与者为2016年在伊朗德黑兰伊玛目霍梅尼医院接受抗逆转录病毒疗法（ART）治疗的67名PLWH。参与者被分为当前CD4细胞计数、基线CD4细胞计数、最低CD4细胞计数和血浆病毒载量水平高和低的两组。我们使用SPSS 22软件通过独立样本t检验进行数据分析。
我们的结果表明，对于当前CD4细胞计数，HRQoL总分的组间差异具有统计学意义（P = 0.028），在身体功能（P = 0.032）、因身体健康问题导致的角色限制（P = 0.006）和因情绪问题导致的角色限制（P = 0.009）等方面也是如此。我们的数据分析表明，对于基线CD4细胞计数（P = 0.62）、最低CD4细胞计数（P = 0.29）和病毒载量组（P = 0.78），HRQoL的差异无统计学意义。
了解当前CD4计数与健康相关生活质量之间的关联后，坚持ART可能会促使PLWH提高其健康相关生活质量。
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