Wan Yang, Baltaze Jean-Pierre, Kouklovsky Cyrille, Miclet Emeric, Alezra Valérie
National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Faculté des Sciences d'Orsay, Laboratoire de Méthodologie, Synthèse et Molécules Thérapeutiques, ICMMO, UMR 8182, CNRS, Université Paris-Saclay, Orsay, France.
J Pept Sci. 2019 Feb;25(2):e3143. doi: 10.1002/psc.3143. Epub 2018 Dec 21.
We have previously reported the synthesis of enantiopure β,γ-diamino acids and relevant short α/γ-peptide containing such building blocks. Complete nuclear magnetic resonance (NMR) studies, together with molecular modeling, highlighted the ability of a β,γ-diamino acid to induce various intramolecular turns. In this paper, we describe for the first time the formation of a dimeric structure constituted by α/γ/α-tripeptide and stabilized by intermolecular interactions. A structural model is proposed based on extensive NMR measurements.
我们之前报道过对映体纯的β,γ-二氨基酸以及含有此类结构单元的相关短α/γ-肽的合成。完整的核磁共振（NMR）研究以及分子模拟突出了β,γ-二氨基酸诱导各种分子内转折的能力。在本文中，我们首次描述了由α/γ/α-三肽构成并通过分子间相互作用稳定的二聚体结构的形成。基于广泛的NMR测量结果提出了一个结构模型。
