Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Pediatr Pulmonol. 2019 Apr;54(4):451-456. doi: 10.1002/ppul.24223. Epub 2018 Dec 21.
The 6-min walk test (6MWT) predicts outcome in pulmonary hypertension. Recently, its use was reported in both cystic fibrosis (CF) and bronchiolitis obliterans (BO). While the 6MWT is a simple, non-invasive and inexpensive tool, lung clearance index (LCI) measurement requires expensive equipment and expertise. We aimed to evaluate 6MWT in BO and CF, and to compare to MBW (multiple breath washout), pulmonary function tests and quality of life (QOL).
A prospective single center study assessing 6MWT, MBW, spirometry, whole-body plethysmography and QOL (SF-36 questionnaire) in BO and CF patients and correlations between them.
Thirty-three BO patients and 37 CF patients. LCI was significantly higher in BO (12.4 ± 4.2 vs 10.5 ± 3.4, P = 0.044) while FEF 25-75% was significantly lower in BO (43.9 ± 24.4 vs 60.8 ± 30.8, P = 0.014). 6MWD was 474.8 ± 76.3 in BO and 506.6 ± 70 in CF (P > 0.05). There was no correlation between 6MWD and LCI in these small study groups There were few correlation between spirometry prameters and 6MWD. In CF, SF-36 scores correlated with pulmonary functions.
The 6MWT is an easy-to-perform test that may be helpful in chronic lung diseases in regions with limited resources. However,with the current limited data, 6MWT cannot replace LCI or spirometry as a marker of disease progression. Is is suggested that, together with QOL, the 6MWT may provide a global estimation of the physiological and general well-being of these patients. Further larger multi-center studies are warranted to evaluate the correlations of 6MWT with pulmonary physiology parameters in various chronic diseases.
6 分钟步行测试（6MWT）可预测肺动脉高压的预后。最近，它在囊性纤维化（CF）和细支气管炎性闭塞（BO）中均有报道。虽然 6MWT 是一种简单、无创且廉价的工具，但肺清除指数（LCI）的测量需要昂贵的设备和专业知识。我们旨在评估 BO 和 CF 中的 6MWT，并将其与 MBW（多次呼吸冲洗）、肺功能测试和生活质量（QOL）进行比较。
一项前瞻性单中心研究，评估了 BO 和 CF 患者的 6MWT、MBW、肺活量测定、全身 plethysmography 和 QOL（SF-36 问卷），并评估了它们之间的相关性。
33 名 BO 患者和 37 名 CF 患者。BO 患者的 LCI 显著更高（12.4±4.2 比 10.5±3.4，P=0.044），而 BO 患者的 FEF 25-75%显著更低（43.9±24.4 比 60.8±30.8，P=0.014）。BO 患者的 6MWD 为 474.8±76.3，CF 患者的 6MWD 为 506.6±70（P>0.05）。在这些小研究组中，6MWD 与 LCI 之间没有相关性。肺功能参数与 6MWD 之间的相关性很少。在 CF 中，SF-36 评分与肺功能相关。
6MWT 是一种易于进行的测试，在资源有限的地区对慢性肺部疾病可能有帮助。然而，根据目前有限的数据，6MWT 不能替代 LCI 或肺功能作为疾病进展的标志物。建议将 6MWT 与 QOL 一起使用，以提供这些患者生理和整体健康状况的综合评估。需要进一步进行更大规模的多中心研究，以评估 6MWT 与各种慢性疾病的肺生理参数之间的相关性。
