Raj Rahul, Rautio Riitta, Pekkola Johanna, Rahi Melissa, Sillanpää Mikko, Numminen Jussi
Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Department of Radiology, Turku University Hospital, Turku, Finland.
World Neurosurg. 2019 Mar;123:e709-e716. doi: 10.1016/j.wneu.2018.12.010. Epub 2018 Dec 19.
The Woven EndoBridge (WEB) device is a new treatment modality developed for broad-necked unruptured intracranial aneurysms (IAs) but shows potential for the treatment of ruptured IAs as well. Our aim was to describe 6-month aneurysm obliteration rates, clinical outcomes, and procedure-related complications after WEB treatment for ruptured IAs from 2 academic centers.
We conducted a retrospective observational study, including all consecutive patients treated with the WEB device (WEB single layer and single-layer sphere) for a ruptured IA causing acute subarachnoid hemorrhage between 2014 (start of use) and 2017. Primary outcome was angiographic aneurysm obliteration (Beaujon Occlusion Scale Score) rate. Secondary outcomes were early re-bleedings, complications, and patient outcome (death and modified Rankin Scale).
A total of 33 patients with ruptured IAs were treated 0-4 days from IA rupture. Of 27 survivors, 6-month angiographic follow-up was available for 26 patients, of whom 81% showed complete occlusion. Of the 27 survivors, 24 patients (89%) had a favorable neurologic outcome at 6 months after subarachnoid hemorrhage. Two aneurysms were retreated (8% of all). There was 1 fatal procedure-related complication. No early aneurysm re-bleedings were noted.
For anatomically suitable ruptured IAs, WEB device treatment seems to be safe and results in acceptable occlusion rates. Still, larger studies with long-term results are needed before recommendations can be made.
编织型血管内桥接(WEB)装置是一种为宽颈未破裂颅内动脉瘤(IA)开发的新型治疗方式,但对破裂IA的治疗也显示出潜力。我们的目的是描述来自两个学术中心的破裂IA患者接受WEB治疗后6个月的动脉瘤闭塞率、临床结局和与手术相关的并发症。
我们进行了一项回顾性观察研究,纳入了2014年(开始使用)至2017年间所有连续接受WEB装置(WEB单层和单层球囊)治疗的因破裂IA导致急性蛛网膜下腔出血的患者。主要结局是血管造影动脉瘤闭塞(博让闭塞量表评分)率。次要结局是早期再出血、并发症和患者结局(死亡和改良Rankin量表)。
共有33例破裂IA患者在IA破裂后0至4天接受治疗。27名幸存者中,26例患者有6个月的血管造影随访,其中81%显示完全闭塞。27名幸存者中,24例(89%)在蛛网膜下腔出血后6个月有良好的神经功能结局。两个动脉瘤接受了再次治疗(占所有患者的8%)。有1例与手术相关的致命并发症。未观察到早期动脉瘤再出血。
对于解剖结构合适的破裂IA,WEB装置治疗似乎是安全的,闭塞率可接受。然而,在提出建议之前,仍需要进行更大规模的长期研究。