Ritchie D M, DiPalma J R, McMichael R F
Arch Int Pharmacodyn Ther. 1978 Jan;231(1):57-62.
Various gases were administered to isolated frog sciatic nerves in which action potential amplitudes were recorded in sheathed and desheathed preparations. In the sheathed preparation, nitrogen and argon showed significant anesthetic effects while in the desheathed preparation, helium also depressed the action potential amplitude. In the desheathed frog sciatic nerve, helium demonstrates an anesthetic effect similar to 10(-6) M lidocaine suggesting that at long exposure periods helium may demonstrate anesthetic properties.
将各种气体施加于分离的青蛙坐骨神经，在有鞘和去鞘制剂中记录动作电位幅度。在有鞘制剂中，氮气和氩气显示出显著的麻醉作用，而在去鞘制剂中，氦气也降低了动作电位幅度。在去鞘的青蛙坐骨神经中，氦气表现出与10(-6)M利多卡因相似的麻醉作用，这表明在长时间暴露时，氦气可能具有麻醉特性。
