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一项关于 75 岁以上老年患者腹主动脉瘤修复术后生活质量和功能状态的系统评价。

A systematic review on the quality of life and functional status after abdominal aortic aneurysm repair in elderly patients with an average age older than 75 years.

机构信息

Department of Vascular Surgery, St. Vincent's Hospital, Melbourne, Victoria, Australia.

Department of Surgery, University of Sydney, Sydney, New South Wales, Australia.

出版信息

J Vasc Surg. 2019 Apr;69(4):1268-1281. doi: 10.1016/j.jvs.2018.09.032. Epub 2018 Dec 19.

Abstract

OBJECTIVE

Endovascular aneurysm repair (EVAR) and open repair (OR) of abdominal aortic aneurysms (AAAs) are increasingly performed in elderly patients (>75 years of age) with satisfactory results. Quality of life (QOL) is increasingly considered a primary goal of intervention after AAA repair. However, there is currently no consensus on QOL after these procedures in elderly patients.

METHODS

A systematic review was performed using strict eligibility criteria. Clinical studies reporting QOL in elderly patients (average age >75 years) after EVAR and OR were included. Quality appraisal and data tabulation were performed using predetermined forms. Data were synthesized by narrative review. Study quality was assessed.

RESULTS

Thirteen studies with 1272 patients were included. After elective EVAR, disease-specific and generic QOL scores demonstrated an initial postoperative deterioration. By 4 to 6 weeks postoperatively, mental health components have improved to scores similar to or better than those at baseline. Physical health components take up to 3 months to return to baseline. After this, 36-Item Short-Form Health Survey and EuroQol-5 Dimension scores are maintained at preoperative levels for 1 to 3 years. In emergent EVAR, long-term survivors may have QOL comparable to that of the general population. Elective OR appears to have comparable QOL for up to 3 years compared with a matched population. QOL after emergent OR seems poor. Data on OR in elderly patients remain limited.

CONCLUSIONS

QOL after EVAR and OR declines early, with a 4- to 6-week delay in mental health recovery and 1- to 3-month delay in physical health recovery. QOL eventually returns to baseline and can be maintained in the long term. This review supports AAA repair in elderly patients from a QOL perspective.

摘要

目的

血管内动脉瘤修复术(EVAR)和开放修复术(OR)治疗腹主动脉瘤(AAA)在年龄较大的患者(>75 岁)中越来越常见,且效果令人满意。生活质量(QOL)越来越被认为是 AAA 修复后干预的主要目标。然而,目前对于老年患者接受这些治疗后的 QOL 尚未达成共识。

方法

使用严格的纳入标准进行系统评价。纳入报告 EVAR 和 OR 后老年患者(平均年龄>75 岁)生活质量的临床研究。使用预定的表格进行质量评估和数据列表。通过叙述性综述综合数据。评估研究质量。

结果

纳入 13 项研究,共 1272 例患者。选择性 EVAR 后,疾病特异性和通用 QOL 评分在术后初期恶化。术后 4 至 6 周,心理健康相关评分改善,达到或优于基线水平。身体状况相关评分则需要 3 个月才能恢复到基线水平。此后,36 项简明健康状况调查问卷和欧洲五维健康量表评分在 1 至 3 年内保持术前水平。在紧急 EVAR 中,长期生存者的 QOL 可能与一般人群相当。择期 OR 在长达 3 年内的 QOL 与匹配人群相当。择期 OR 的 QOL 似乎较差。关于老年患者 OR 的数据仍然有限。

结论

EVAR 和 OR 后的 QOL 早期下降,心理健康恢复延迟 4 至 6 周,身体恢复延迟 1 至 3 个月。QOL 最终恢复到基线水平并可长期维持。该综述从 QOL 的角度支持对老年患者进行 AAA 修复。

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