白细胞介素-13：自身免疫性疾病有前途的治疗靶点。

Interleukin-13: A promising therapeutic target for autoimmune disease.

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China.

Anhui Academy of Medical Sciences, 15 Yonghong Road, Hefei, Anhui, China.

出版信息

Cytokine Growth Factor Rev. 2019 Feb;45:9-23. doi: 10.1016/j.cytogfr.2018.12.001. Epub 2018 Dec 12.

DOI:10.1016/j.cytogfr.2018.12.001

PMID:30581068

Abstract

Interleukin-13 (IL-13) was previously thought to be a redundant presence of IL-4, but in recent years its role in immunity, inflammation, fibrosis, and allergic diseases has become increasingly prominent. IL-13 can regulate several subtypes of T helper (Th) cells and affect their transformation, including Th1, Th2, T17, etc., thus it may play an important role in immune system. Previous studies have revealed that IL-13 is implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), ulcerative colitis (UC), type 1 diabetes (T1D), sjogren's syndrome (SS), etc. In this review, we will briefly discuss the biological features of IL-13 and summarize recent advances in the role of IL-13 in the development and pathogenesis of autoimmune diseases. This information may provide new perspectives and suggestions for the selection of therapeutic targets for autoimmune diseases.

摘要

白细胞介素-13（IL-13）以前被认为是 IL-4 的冗余存在，但近年来，它在免疫、炎症、纤维化和过敏性疾病中的作用变得越来越突出。IL-13 可以调节几种辅助性 T 细胞（Th）亚型，并影响它们的转化，包括 Th1、Th2、T17 等，因此它可能在免疫系统中发挥重要作用。先前的研究表明，IL-13 参与了自身免疫性疾病的发病机制，如系统性红斑狼疮（SLE）、类风湿关节炎（RA）、系统性硬皮病（SSc）、溃疡性结肠炎（UC）、1 型糖尿病（T1D）、干燥综合征（SS）等。在这篇综述中，我们将简要讨论 IL-13 的生物学特征，并总结 IL-13 在自身免疫性疾病发展和发病机制中的作用的最新进展。这些信息可能为自身免疫性疾病治疗靶点的选择提供新的视角和建议。