急性高碳酸血症对脑内吲哚胺代谢的影响。
The effects of acute hypercapnia on cerebral indole amine metabolism.
作者信息
MacMillan V
出版信息
Can J Physiol Pharmacol. 1978 Apr;56(2):223-6. doi: 10.1139/y78-032.
The effects of 1-h exposure to hypercapnia (PaCO2, 90-110 MMHg) on cerebral indole amine metabolism were studied in rats by measurement of cerebral hemisphere contents of tryptophan, 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA), 5-HIAA content was increased after 1-h exposure to hypercapnia, whereas tryptophan, 5-HTP, and 5-HT remained unchanged from control. The accumulation of 5-HTP after decarboxylase inhibition with 3-hydroxybenzyl hydrazine was increased in hypercapnic rats and indicated an increased activity of tryptophan hydroxylase. During the 1-h exposure to hypercapnia there was increased accumulation of 5-HT after monoamine oxidase inhibition with pargyline and increased accumulation of 5-HIAA arter probenecid. The results indicate an increased synthesis and degradation of indole amines in acute hypercapnia.
通过测量大鼠大脑半球中色氨酸、5-羟色氨酸（5-HTP）、5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的含量，研究了大鼠暴露于高碳酸血症（动脉血二氧化碳分压，90 - 110 mmHg）1小时对脑内吲哚胺代谢的影响。暴露于高碳酸血症1小时后，5-HIAA含量增加，而色氨酸、5-HTP和5-HT与对照组相比保持不变。用3-羟基苄基肼抑制脱羧酶后，高碳酸血症大鼠体内5-HTP的积累增加，这表明色氨酸羟化酶的活性增强。在暴露于高碳酸血症的1小时内，用优降宁抑制单胺氧化酶后5-HT的积累增加，用丙磺舒后5-HIAA的积累增加。结果表明，急性高碳酸血症时吲哚胺的合成和降解增加。
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