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甲状腺功能减退症时睾丸的弹性成像及形态学变化——一项实验研究

Elastographic and Morphological Testicular Changes in Hypothyroidism - An Experimental Study.

作者信息

Gołyński Marcin, Dębiak Piotr, Gołyńska Magdalena, Myśliwiec Ewa, Szkodziak Piotr, Kalisz Grzegorz, Śmiech Anna, Lutnicki Krzysztof, Szczepanik Marcin

机构信息

Department and Clinic of Animal Internal Diseases, Lublin, Poland.

Laboratory of Radiology and Ultrasonography, Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland.

出版信息

J Vet Res. 2018 Dec 10;62(3):347-352. doi: 10.2478/jvetres-2018-0049. eCollection 2018 Sep.

DOI:10.2478/jvetres-2018-0049
PMID:30584615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6296000/
Abstract

INTRODUCTION

Methimazole-induced hypothyroidism is a clinical problem in the treatment of hyperthyroidism in people and animals and is an example of metabolic disease that can lead to fertility disorders and can give elastographic testicular changes.

MATERIAL AND METHODS

Ultrasound elastography using the Esaote MyLab Twice ultrasound system and a morphological examination of testes were performed in seven methimazole-administered (group E) and seven healthy rats (group C).

RESULTS

The elasticity ratio of strains in the scrotal wall of the near-field test area to testicular tissue (ELX-T-RAT) and hardness percentage of strained tissues in the defined area of a testicle (ELX-T%HRD) in group E were statistically significantly lower than in group C. The degree of spermatogenesis was statistically significantly higher in group E than in group C and similarly seminiferous tubule diameters in group E were statistically significantly higher than in group C. Body weight and testicular weight in group E were statistically significantly lower than in group C.

CONCLUSION

Changes in the elastographical parameters of testes may result from disorders secondary to hypothyroidism. The usefulness of elastography is noteworthy in the case of evaluation of testis function in patients with some metabolic disorders.

摘要

引言

甲巯咪唑诱发的甲状腺功能减退是人和动物甲状腺功能亢进治疗中的一个临床问题，是一种可导致生育障碍并能引起睾丸弹性成像改变的代谢性疾病的实例。

材料与方法

使用百胜MyLab Twice超声系统对7只给予甲巯咪唑的大鼠（E组）和7只健康大鼠（C组）进行睾丸超声弹性成像及形态学检查。

结果

E组近场检测区域阴囊壁与睾丸组织的应变弹性比值（ELX-T-RAT）以及睾丸特定区域应变组织的硬度百分比（ELX-T%HRD）在统计学上显著低于C组。E组的精子发生程度在统计学上显著高于C组，同样，E组的生精小管直径在统计学上也显著高于C组。E组的体重和睾丸重量在统计学上显著低于C组。

结论

睾丸弹性成像参数的变化可能源于甲状腺功能减退继发的紊乱。在评估某些代谢紊乱患者的睾丸功能时，弹性成像的实用性值得关注。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/e1fd2b6113d6/jvetres-62-347-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/41beb973d4ff/jvetres-62-347-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/ee121312b064/jvetres-62-347-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/ed7191bdacc8/jvetres-62-347-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/e1fd2b6113d6/jvetres-62-347-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/41beb973d4ff/jvetres-62-347-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/ee121312b064/jvetres-62-347-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/ed7191bdacc8/jvetres-62-347-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a79a/6296000/e1fd2b6113d6/jvetres-62-347-g004.jpg

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本文引用的文献

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Testicular Shear Wave Elastography in Normal and Infertile Men: A Prospective Study on 601 Patients.正常男性与不育男性的睾丸剪切波弹性成像：601例患者的前瞻性研究
Ultrasound Med Biol. 2017 Apr;43(4):782-789. doi: 10.1016/j.ultrasmedbio.2016.11.016. Epub 2017 Jan 3.
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FDA-approved medications that impair human spermatogenesis.经美国食品药品监督管理局批准的会损害人类精子发生的药物。
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Multiparametric ultrasonography of the pediatric scrotum and in boys with undescended testes.
小儿阴囊及隐睾男孩的多参数超声检查
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Shear wave elastography (SWE) is reliable method for testicular spermatogenesis evaluation after torsion.剪切波弹性成像（SWE）是评估睾丸扭转后精子发生情况的可靠方法。
Int J Clin Exp Med. 2015 May 15;8(5):7089-97. eCollection 2015.
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Adverse effects of common medications on male fertility.常见药物对男性生育力的不良影响。
Nat Rev Urol. 2015 Jul;12(7):401-13. doi: 10.1038/nrurol.2015.145. Epub 2015 Jun 23.
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Diagnostic role of conventional ultrasonography and shearwave elastography in asymptomatic patients with diffuse thyroid disease: initial experience with 57 patients.常规超声及剪切波弹性成像在无症状弥漫性甲状腺疾病患者中的诊断价值：57 例患者的初步经验。
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Inhibin B levels in hypothyroid males.甲状腺功能减退男性的抑制素 B 水平。
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