a Postgraduate Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine , Maringá State University , Maringá , Brazil.
b Immunogenetics Laboratory, Department of Basic Health Sciences , Maringá State University , Maringá , Brazil.
Expert Rev Clin Immunol. 2019 Mar;15(3):303-313. doi: 10.1080/1744666X.2019.1564039. Epub 2019 Jan 24.
Psoriatic arthritis (PsA) is a chronic skin and joint condition that considerably affects patient quality of life. Several studies have demonstrated different associations of genetic polymorphisms in the pathogenic process of PsA. Therefore, we conducted a meta-analysis to estimate the effect of polymorphisms in the cytokines TNF, IL12B, IL23A, and IL23R on PsA risk.
We screened 1,097 abstracts and identified 14 relevant studies published between January 2007 and December 2017. A systematic search was conducted in PubMed, Web of Knowledge and Scopus databases. Meta-analyses were performed for the comparisons of alleles and multiple genetic models.
Among the cytokines studied, we found 17 polymorphisms that were the most investigated. The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), -308 G > A (rs1800629), and -857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026).
Our findings suggest that these variant cytokine genes may strongly influence the immunological response of PsA.
银屑病关节炎（PsA）是一种慢性皮肤和关节疾病，极大地影响了患者的生活质量。多项研究已经证实了遗传多态性在 PsA 发病机制中的不同关联。因此，我们进行了一项荟萃分析，以评估细胞因子 TNF、IL12B、IL23A 和 IL23R 中的多态性对 PsA 风险的影响。
我们筛选了 1097 篇摘要，并确定了 2007 年 1 月至 2017 年 12 月期间发表的 14 项相关研究。在 PubMed、Web of Knowledge 和 Scopus 数据库中进行了系统搜索。对等位基因和多种遗传模型的比较进行了荟萃分析。
在所研究的细胞因子中，我们发现了 17 个最受关注的多态性。在存在以下多态性的情况下，与 PsA 相关：TNF-238 G > A（rs361525）、-308 G > A（rs1800629）和-857 C > T（rs1799724）；IL12B C > G（rs6887695）和 A > C（rs3212227）；IL23A A > G（rs2066808）和 IL23R G > A（rs11209026）。
我们的研究结果表明，这些变异细胞因子基因可能强烈影响 PsA 的免疫反应。
