a Department of Otolaryngology-Head and Neck Surgery , Stanford University School of Medicine , Stanford , CA , USA.
Expert Opin Biol Ther. 2019 Feb;19(2):129-139. doi: 10.1080/14712598.2019.1564035. Epub 2019 Jan 2.
Sound is integral to communication and connects us to the world through speech and music. Cochlear hair cells are essential for converting sounds into neural impulses. However, these cells are highly susceptible to damage from an array of factors, resulting in degeneration and ultimately irreversible hearing loss in humans. Since the discovery of hair cell regeneration in birds, there have been tremendous efforts to identify therapies that could promote hair cell regeneration in mammals.
Here, we will review recent studies describing spontaneous hair cell regeneration and direct cellular reprograming as well as other factors that mediate mammalian hair cell regeneration.
Numerous combinatorial approaches have successfully reprogrammed non-sensory supporting cells to form hair cells, albeit with limited efficacy and maturation. Studies on epigenetic regulation and transcriptional network of hair cell progenitors may accelerate discovery of more promising reprogramming regimens.
声音是交流不可或缺的一部分,通过言语和音乐将我们与世界联系在一起。耳蜗毛细胞是将声音转化为神经冲动的关键。然而,这些细胞极易受到多种因素的损伤,导致人类的毛细胞退化和最终不可逆转的听力损失。自鸟类的毛细胞再生被发现以来,人们一直在努力寻找可以促进哺乳动物毛细胞再生的疗法。
在这里,我们将回顾最近描述自发毛细胞再生和直接细胞重编程以及其他介导哺乳动物毛细胞再生的因素的研究。
许多组合方法已经成功地将非感觉支持细胞重编程为毛细胞,但效果和成熟度有限。对毛细胞祖细胞的表观遗传调控和转录网络的研究可能会加速发现更有前途的重编程方案。