Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.
Universidad Andrés Bello, Viña del Mar, Chile.
Nat Prod Res. 2020 Aug;34(16):2310-2314. doi: 10.1080/14786419.2018.1531402. Epub 2018 Dec 25.
In this study, resinous exudate from was analyzed by GC-MS. The major bioactive compounds 13,14,15-trihydroxylabd-7-ene () and 3,14,15-trihydroxylabd-8-ene () were isolated and their structures were determined by NMR. The antifungal activity of the resinous exudate and the labdanes compounds was evaluated using the inhibitory effects on the mycelial growth of plant pathogen causing root rot of various crops. The evaluation of the resinous exudate showed no inhibition over 50% at 75 mg/L, while compound had the stronger effect on the myceliar growth of , with a 94.6% inhibition at 175 mg/L. The same way, the mixture of both compounds in equal parts did not show a synergistic effect but showed similar percentages of mycelial growth inhibition from 25 mg/L with respect to the compounds separately.
在这项研究中，我们通过 GC-MS 分析了树脂状分泌物。从树脂状分泌物中分离出了具有生物活性的化合物 13,14,15-三羟基-7-烯（）和 3,14,15-三羟基-8-烯（），并通过 NMR 确定了它们的结构。采用对引起各种作物根腐病的植物病原菌的菌丝生长的抑制作用来评估树脂状分泌物和拉伯烷类化合物的抗真菌活性。评估结果表明，在 75μg/ml 时，树脂状分泌物的抑制率没有超过 50%，而化合物则对的菌丝生长有更强的抑制作用，在 175μg/ml 时的抑制率为 94.6%。同样，以相同比例混合的两种化合物并没有表现出协同作用，而是在 25μg/ml 时表现出与单独使用化合物时相似的菌丝生长抑制百分比。
