[Genetic differences of antigens controlled by Y chromosome ensure the inactivation of bone marrow stem cells by syngeneic murine lymphocytes].

Expression of the inactivation effect of the stem colony-forming marrow cells of male mice CBA, C57B1/6, (CBA.C57B1/6)F1 and (C57B1/6.CBA)F1 by syngeneic lymphocytes of lymphatic nodes of females in conditions of transplantation of cell mixtures into lethally irradiated recipients was studied. The maximum inactivation effect of stem cells (86.3%) is determined in mice F1 with differences of H-Y antigen, the minimum effect (2.4%)--in mice CBA, an intermediate effect (54%) being registered in mice C57B1/6. Sensibility of target cells to the inactivation influence of lymphocytes distinguished by weak transplantation H-Y antigen depended on the maternal effect and direction of reaction. The inactivation effect was maximal in the combination CBA----C57B1/6 and C57B1/6----C57B1/6, as compared with the combination CBA----CBA and C57B1/6----CBA. Possible mechanisms by which the killer action of syngeneic lymphocytes on the antigen H-Y of target cells is developed differently, are under discussion.