Surkov A N, Namazova-Baranova L S, Gevorkyan A K
Klin Lab Diagn. 2016 Apr;61(4):209-14.
The chronic viral hepatitis is characterized by progressing course. In connection with this fact, there is a risk of development of fibrosis of liver. The diagnostic of this disease biopsy is applied as main technique. However, this invasive procedure is not always safe for patient. Therefore, it is applied only in specialized institutions, requires special training of medical personnel and has a number of contraindications. In recent years, in the capacity of noninvasive diagnostic of different stages of fibrosis of liver a number of serum markers are considered. Among them, the most number of studies concerns hyaluronic acid, collagen type IV, matrix metalloproteinase and their tissue inhibitors, transforming growth factor β. The review presents actual information concerning possibilities of application of these serological indices in practical medicine in patients with chronic viral hepatitis.
慢性病毒性肝炎的特点是病程进展。鉴于这一事实，存在肝脏纤维化发展的风险。该病的诊断活检作为主要技术应用。然而，这种侵入性操作对患者并非总是安全的。因此，它仅在专科医院应用，需要医务人员接受特殊培训且有许多禁忌症。近年来，作为肝脏纤维化不同阶段的非侵入性诊断方法，一些血清标志物被考虑在内。其中，研究最多的是透明质酸、IV型胶原、基质金属蛋白酶及其组织抑制剂、转化生长因子β。本综述提供了有关这些血清学指标在慢性病毒性肝炎患者实际医学应用可能性的最新信息。
