Shaheryar Zaib Ali, Rehman Zakaur, Zaman Muhammad, Shah Shahid, Khan Kashifur Rahman, Khan Sajid Mahmood, Amjad Muhammad Wahab, Raja Maria Abdul Ghafoor, Zaidi Awais Ali
Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
Pak J Pharm Sci. 2018 Nov;31(6 (Supplementary):2743-2747.
This study was schemed to comprehend the latest kaleidoscopic trends of bacterial resistance in neonatal pathogens against all those antibiotics commonly employed as empirical therapy in neonates. The methodological approach included; isolation and subsequent identification of those pathogens having caused bacterial infections in neonates, application of antibiotic sensitivity testing and finally construing the conclusion depicting patterns of antibiotic resistance by various pathogens, isolated from neonatal biological samples. Antibiotic resistance patterns was evident in gram-positive as well as in gram-negative bacteria in all the eight species identified in this study. Even antibiotic drugs which are being commonly relied upon for treating multi-resistant bacterial infections, found to be in effective against many newly emerged resistant bacteria, when used alone. Resistance Antibiotics drugs against which most prominent resistance pattern emerged include; Amikacin sulphate, Linezolid, Piperacillin / Tazobactam, Amoxicillin / Clavulanic acid, Vencomycin, Cefoperazone / Sulbactam, Ceftriaxone sodium, Ciprofloxacin, Cefixime trihydrate and Imipenem. The inferred upshot suggests that antibiotic resistance is emerging fast and ever-changing phenomenon of antibiotic resistance has significantly reduced the therapeutic space to maneuver, particularly, in treating neonatal infections.
本研究旨在了解新生儿病原体对所有常用于新生儿经验性治疗的抗生素的最新细菌耐药的千变万化趋势。方法包括：分离并随后鉴定在新生儿中引起细菌感染的病原体，应用抗生素敏感性测试，最后得出结论，描述从新生儿生物样本中分离出的各种病原体的抗生素耐药模式。在本研究鉴定的所有八个菌种中，革兰氏阳性菌和革兰氏阴性菌均出现了抗生素耐药模式。甚至那些通常用于治疗多重耐药细菌感染的抗生素药物，单独使用时也发现对许多新出现的耐药细菌无效。出现最显著耐药模式的抗生素药物包括：硫酸阿米卡星、利奈唑胺、哌拉西林/他唑巴坦、阿莫西林/克拉维酸、万古霉素、头孢哌酮/舒巴坦、头孢曲松钠、环丙沙星、三水合头孢克肟和亚胺培南。推断结果表明，抗生素耐药性正在迅速出现，而且不断变化的抗生素耐药现象显著减少了治疗的操作空间，尤其是在治疗新生儿感染方面。
