Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee.
Clin Cancer Res. 2019 Mar 1;25(5):1452-1454. doi: 10.1158/1078-0432.CCR-18-3858. Epub 2018 Dec 26.
Immune checkpoint inhibitors induce durable responses in some patients with advanced cancer but may simultaneously trigger autoinflammatory immune-related adverse events (irAE). The pathogenesis of irAEs may relate to genetic predisposition, environmental insults, or tumor-host interactions. Elevated expression of certain cytokines may signal subclinical inflammation that evolves into severe irAEs with treatment..
免疫检查点抑制剂可诱导部分晚期癌症患者产生持久反应,但也可能同时引发自身炎症性免疫相关不良事件(irAE)。irAE 的发病机制可能与遗传易感性、环境损伤或肿瘤-宿主相互作用有关。某些细胞因子的表达升高可能预示着亚临床炎症,进而发展为严重的 irAE。