中分子肝素化苯丙氨酸对Ⅰ型超敏反应的影响
Effects of Medium Molecular Weight Heparinyl Phenylalanine on Type I Hypersensitivity.
作者信息
Takeda Seiichi, Toda Takao, Nakamura Kazuki
机构信息
Research and Development Center, Fuso Pharmaceutical Industries Ltd, Osaka, Japan
Research and Development Center, Fuso Pharmaceutical Industries Ltd, Osaka, Japan.
出版信息
In Vivo. 2019 Jan-Feb;33(1):53-55. doi: 10.21873/invivo.11438.
BACKGROUND/AIM: We investigated the inhibitory action of medium molecular weight heparinyl phenylalanine (MHF) on type I hypersensitivity in comparison with medium molecular weight heparinyl arginine (MHR).
MATERIALS AND METHODS
MHF and MHR were synthesized from heparin (HE) to decrease the side-effect of HE based on its anticoagulant action and used in this study.
RESULTS
MHF demonstrated a significant inhibitory action on 48-h homologous passive cutaneous anaphylaxis in rats. Although MHF did not affect the death of mice injected with a lethal dose of histamine, it significantly prolonged the survival time of mice administered a lethal dose of compound 48/80. On the other hand, MHR did not inhibit type I hypersensitivity.
CONCLUSION
The inhibitory action of MHF on the type I allergic reaction was due to a reduction or delay in histamine release from mast cells. MHF may be a potent anti-allergic agent.
背景/目的：我们研究了中分子量肝素苯丙氨酸（MHF）与中分子量肝素精氨酸（MHR）相比对I型超敏反应的抑制作用。
材料与方法
基于肝素（HE）的抗凝作用，从肝素合成了MHF和MHR以降低HE的副作用，并用于本研究。
结果
MHF对大鼠48小时同源被动皮肤过敏反应表现出显著的抑制作用。虽然MHF不影响注射致死剂量组胺的小鼠的死亡，但它显著延长了给予致死剂量化合物48/80的小鼠的存活时间。另一方面，MHR不抑制I型超敏反应。
结论
MHF对I型过敏反应的抑制作用是由于肥大细胞组胺释放减少或延迟。MHF可能是一种有效的抗过敏剂。
Zotero 插件