含脂多糖保湿霜对轻度特应性皮炎患者皮肤护理的影响。
The Effect of Lipopolysaccharide-containing Moisturizing Cream on Skin Care in Patients With Mild Atopic Dermatitis.
作者信息
Nakai Kozo, Kubota Yasuo, Soma Gen-Ichiro, Kohchi Chie
机构信息
Department of Dermatology, School of Medicine, Kagawa University, Kita-gun, Japan.
Control of Innate Immunity, Technology Research Association, Takamatsu, Japan.
出版信息
In Vivo. 2019 Jan-Feb;33(1):109-114. doi: 10.21873/invivo.11446.
BACKGROUND/AIM: Recently, the prevalence of atopic dermatitis (AD) has increased in developed countries. This study aimed to examine the usefulness of a moisturizing cream containing lipopolysaccharide derived from Pantoea agglomerans (LPSp) in patients with mild AD.
PATIENTS AND METHODS
A moisturizing cream containing LPSp or its placebo was randomly assigned and continuously used for 4 weeks in patients with mild AD. AD severity was evaluated in a double-blind manner by a dermatologist using the Eczema Area and Severity Index (EASI) score and by the patients' self-evaluation of itching and skin condition using a visual analog scale (VAS).
RESULTS
Although there was no difference in the EASI score between the two groups, the VAS scores showed significantly greater symptom alleviation in the LPSp group than in the placebo group.
CONCLUSION
A moisturizing cream containing LPSp may be effective for routine skin care and could help alleviate symptoms of mild AD.
背景/目的：近年来，发达国家特应性皮炎（AD）的患病率有所上升。本研究旨在探讨含有成团泛菌来源的脂多糖（LPSp）的保湿霜对轻度AD患者的有效性。
患者与方法
将含有LPSp的保湿霜或其安慰剂随机分配给轻度AD患者，并持续使用4周。皮肤科医生采用湿疹面积和严重程度指数（EASI）评分以双盲方式评估AD严重程度，患者则使用视觉模拟量表（VAS）对瘙痒和皮肤状况进行自我评估。
结果
尽管两组之间的EASI评分没有差异，但VAS评分显示LPSp组的症状缓解程度明显高于安慰剂组。
结论
含有LPSp的保湿霜可能对日常皮肤护理有效，并有助于缓解轻度AD的症状。
Zotero 插件