Marwaha Raman Kumar, Mithal A, Bhari Neetu, Sethuraman G, Gupta Sushil, Shukla Manoj, Narang Archana, Chadda Aditi, Gupta Nandita, Sreenivas V, Ganie M A
International Life Sciences Institute, India. Correspondence to: Maj Gen Raman Kumar Marwaha, Scientific Advisor (Projects), International Life Science Institute (India).
Medanta Hospital Gurgaon, Haryana, India.
Indian Pediatr. 2018 Nov 15;55(11):951-956.
To compare the adequacy and efficacy of different doses of vitamin D3 in pre-pubertal girls.
Cluster Randomized controlled trial.
Public school in Delhi, India, between August 2015 and February 2016.
216 healthy pre-pubertal girls, aged 6.1-11.8 years.
Daily supplementation with 600 IU (n=74), 1000 IU (n=67) or 2000 IU (n=75) of vitamin D3 under supervision for 6 months.
Primary: Rise in serum 25 hydroxy Vitamin D (25(OH)D); Secondary: Change in bone formation and resorption markers.
Following 6 months of supplementation, the mean (SD) rise in serum 25(OH)D was maximum with 2000 IU (24.09 (8.28) ng/mL), followed by with 1000 IU (17.96 (6.55) ng/mL) and 600 IU (15.48 (7.00) ng/mL). Serum 25(OH)D levels of ≥20 ng/mL were seen in 91% in 600 IU group , 97% in 1000 IU group and 100% in 2000 IU group. The overall mean (SD) rise in urinary calcium creatinine ratio (0.05 (0.28) to 0.13 (0.12) mg/mg), and serum procollagen type I N-terminal propeptide (538.9 (199.78) to 655.5 (218.24) ng/mL), and reduction in serum carboxy-terminal telopeptide (0.745 (0.23) to 0.382 (0.23) ng/mL) was significant (P<0.01). The change in the above parameters was comparable among the three groups after adjustment for age.
Daily vitamin D supplementation with 600 IU to 2000 IU for 6 months results in Vitamin D sufficiency in >90% of pre-pubertal girls.
比较不同剂量维生素D3对青春期前女孩的充足性和有效性。
整群随机对照试验。
2015年8月至2016年2月期间，印度德里的公立学校。
216名健康的青春期前女孩，年龄在6.1 - 11.8岁之间。
在监督下每日补充600国际单位（n = 74）、1000国际单位（n = 67）或2000国际单位（n = 75）的维生素D3，持续6个月。
主要指标：血清25羟维生素D（25(OH)D）升高；次要指标：骨形成和骨吸收标志物的变化。
补充6个月后，血清25(OH)D的平均（标准差）升高幅度以2000国际单位组最大（24.09（8.28）ng/mL），其次是1000国际单位组（17.96（6.55）ng/mL）和600国际单位组（15.48（7.00）ng/mL）。600国际单位组中91%的女孩血清25(OH)D水平≥20 ng/mL，1000国际单位组为97%，2000国际单位组为100%。尿钙肌酐比值总体平均（标准差）升高（从0.05（0.28）mg/mg至0.13（0.12）mg/mg），血清I型前胶原N端前肽升高（从538.9（199.78）ng/mL至655.5（218.24）ng/mL），血清羧基末端肽降低（从0.745（0.23）ng/mL至0.382（0.23）ng/mL），差异有统计学意义（P<0.01）。调整年龄后，三组上述参数的变化具有可比性。
每日补充600国际单位至2000国际单位的维生素D，持续6个月，可使超过90%的青春期前女孩达到维生素D充足状态。
