Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan,
Int J Nanomedicine. 2018 Dec 11;13:8473-8485. doi: 10.2147/IJN.S179484. eCollection 2018.
Alzheimer's disease (AD), an age-related neurodegenerative disease, the most common causes of dementia is a multifactorial pathology categorized by a complex etiology. Numerous nutraceuticals have been clinically evaluated, but some of the trials failed. However, natural compounds have some limitations due to their poor bioavailability, ineffective capability to cross the blood-brain barrier, or less therapeutic effects on AD. To overcome these disadvantages, nanoparticle-conjugated natural products could promote the bioavailability and enhance the therapeutic efficacy of AD when compared with a naked drug. This application generates and implements new prospect for drug discovery in neurodegenerative diseases. In this article, we confer AD pathology, review natural products in clinical trials, and ascertain the importance of nanomedicine coupled with natural compounds for AD.
阿尔茨海默病（AD）是一种与年龄相关的神经退行性疾病，是痴呆症最常见的病因之一，其病理具有多因素的特点，病因复杂。已有大量的营养保健品经过了临床评估，但其中一些试验失败了。然而，由于天然化合物的生物利用度差、穿过血脑屏障的能力有限，或者对 AD 的治疗效果较差，它们存在一些局限性。为了克服这些缺点，与裸药相比，纳米粒子结合的天然产物可以提高生物利用度并增强 AD 的治疗效果。这种应用为神经退行性疾病的药物发现开辟了新的前景。在本文中，我们讨论了 AD 的病理，回顾了临床试验中的天然产物，并确定了纳米医学与天然化合物相结合对 AD 的重要性。
